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Trimethylsilylcyanation of Heterocyclic Aldimines - Derivatives of 2-Trifluoromethylaniline

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The addition of trimethylsilyl cyanide to the CH=N bond of furan, thiophene, and pyridine azomethines in the presence of aluminum bromide as catalyst was studied. The effect of the CF3 group in the aldimines produced by the condensation of O-, S-, and N-heteroaromatic aldehydes with 2-trifluoromethylaniline on the reaction and also other relationships of the investigated processes were studied. The corresponding furan, thiophene, and pyridine α-amino nitriles were synthesized.

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REFERENCES

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Iovel, I., Golomba, L., Popelis, J. et al. Trimethylsilylcyanation of Heterocyclic Aldimines - Derivatives of 2-Trifluoromethylaniline. Chemistry of Heterocyclic Compounds 39, 721–725 (2003). https://doi.org/10.1023/A:1025682726008

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  • DOI: https://doi.org/10.1023/A:1025682726008

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