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Qualitative Assessment of Selective Blockade of M4-Cholinoreceptors in the Whole Organism

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Abstract

Quantitative assessment of selective blockade of M4-subtype muscarinic receptors was performed by the number of pilocarpine-induced movements of lower jaw in rats. Three antagonists (atropine, cyclodol, and glipin) were used in the experiments. Glipin produced the most potent blockade of M4 receptors in the whole organism compared to other test antagonist.

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Authors and Affiliations

  1. Institute of Toxicology, Ministry of Health of the Russian Federation, St. Petersburg

    S. G. Dagaev, A. B. Kosmachev, N. M. Libman, L. G. Kubarskaya, A. V. Khrabrova, V. I. Sanotskii, O. A. Fil'ko & V. B. Dolgo-Saburov

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  1. S. G. Dagaev
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  2. A. B. Kosmachev
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  3. N. M. Libman
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  4. L. G. Kubarskaya
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  5. A. V. Khrabrova
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  6. V. I. Sanotskii
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  7. O. A. Fil'ko
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  8. V. B. Dolgo-Saburov
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Correspondence to S. G. Dagaev.

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Dagaev, S.G., Kosmachev, A.B., Libman, N.M. et al. Qualitative Assessment of Selective Blockade of M4-Cholinoreceptors in the Whole Organism. Bulletin of Experimental Biology and Medicine 135, 445–446 (2003). https://doi.org/10.1023/A:1024959224208

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  • DOI: https://doi.org/10.1023/A:1024959224208

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