Abstract
Four production methods of 177Lu, e.g. from natural and enriched Lu and from natural and enriched Yb were considered and experimentally evaluated. The samples of all 4 materials were irradiated in a nuclear reactor, the activity of 177Lu measured and compared with a computed one. In the case of 177Lu produced from enriched Lu target the amount of activity obtained is 40 to 70% higher than calculated. The results achieved will be applied for the optimization of 177Lu production for medical applications.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. Schlom, K. Siler, D. E. Milenic, D. Eggensperger, D. Colcher, L. S. Miller, D. Houchens, Cheng, D. Kaplan, W. Goeckeler, Cancer Res., 51 (1991) 2889.
S. M. Qaim, Radiochim. Acta, 89 (2001) 297.
P. M. Smith-Jones, S. Vallabhajosula, S. St. Omer, V. Navarro, S. J. Goldsmith, N. H. Bander, J. Labelled Compd. Radiopharm., 44,Supl. 1 (2000) S90.
C. J. Smith, T. J. Hoffman, D. L. Hayes, N. K. Owen, G. L. Sieckman, W. A. Volkert, J. Labelled Compd. Radiopharm., 44,Supl. 1 (2000) S706.
G. A. Rutty Sola, M. G. Argueles. D. L. Bottazini, J. C. Furnari, I. Gomes Parada, A. Rojo, H. V. Ruiz, Radiochim. Acta, 88 (2000) 157.
Handbook of Nuclear Activation Data, Technical Reports Series No. 273, IAEA, Vienna, 1987.
R. B. Firestone, Table of Isotopes, 8th ed., CD Rom, March 1996.
U. Schotzig, H. Schrader, E. SchÖnfeld, E. Gunther, R. Klein, Appl. Radiation Isotopes, 55 (2001) 89.
S. A. Reynolds, W. T. Mullins, Intern. J. Appl. Radiation Isotopes, 14 (1963) 421.
D. Ma, A. R. Ketring, G. J. Ehrhardt, W. Jia, J. Radioanal. Nucl. Chem., 206 (1996) 119.
P. S. Balasubramanian, J. Radioanal. Nucl. Chem., 185 (1994) 305.
N. A. Lebedev, A. F. Novgorodov, J. Brockmann, F. RÖsch, J. Labelled Compd. Radiopharm., 42,Supl. 1 (1999) S924.
N. Toda, Y. Shirota, K. Sakamoto, J. Radioanal. Nucl. Chem., 92 (1985) 333.
A. I. Aliev, W. I. Drynkin, D. I. Leypunskaya, W. A. Kasatkin, Yadernophysicheskiye Konstanty dla Neytronnogo Aktivationnogo Analiza, Atomizdat, Moskva, 1969.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mikolajczak, R., Parus, J.L., Pawlak, D. et al. Reactor produced 177Lu of specific activity and purity suitable for medical applications. Journal of Radioanalytical and Nuclear Chemistry 257, 53–57 (2003). https://doi.org/10.1023/A:1024784924154
Issue Date:
DOI: https://doi.org/10.1023/A:1024784924154