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Synthesis of Water-Soluble Chemodegradable N-Vinylpyrrolidone-Crotonic Acid-2-Hydroxyethyl Methacrylate Terpolymers Containing Interchain Urethane Cross-Links, as Carriers of Substances with Antimicrobial Activity

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Abstract

Water-soluble branched N-vinylpyrrolidone-crotonic acid-2-hydroxyethyl methacrylate terpolymers containing labile interchain urethane cross-links were prepared. Their molecular-weight characteristics were determined, and the hydrolytic stability under conditions close to those in a living body was evaluated. Polymeric salts of gentamicin were prepared from linear and branched chemodegradable N-vinylpyrrolidone terpolymers.

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Solovskii, M.V., Nikol'skaya, N.V., Denisov, V.M. et al. Synthesis of Water-Soluble Chemodegradable N-Vinylpyrrolidone-Crotonic Acid-2-Hydroxyethyl Methacrylate Terpolymers Containing Interchain Urethane Cross-Links, as Carriers of Substances with Antimicrobial Activity. Russian Journal of Applied Chemistry 76, 275–279 (2003). https://doi.org/10.1023/A:1024662915043

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