Abstract
It has been reported that different polymorphisms in the regulatory regions of CCR5 and in the CCR2 gene of the chemokine receptors are associated with AIDS. We decided to determine the congruence between CCR5-59653T and CCR2-64I alleles in a a group of 281 persons. Frequencies of combined CCR5-59653T and CCR2-64I haplotypes were examined in a group of 281 persons. Among 281 individuals 26 (9.3%) and 24 (8.5%) respectively were carriers of the CCR5-59653T and the CCR2-64I alleles. We also found that 24 persons (8.5%) were carriers of combined CCR2-64I/CCR5-59653T allele. The calculation of the congruence revealed that 92.0% of individuals exhibited the same genotype for both CCR2-64I and CCR5-59653T polymorphisms. Our results confirm that linkage between CCR5-59653T and CCR2-64I alleles is not absolute.
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Martin, M.P., Dean, M., Smith, M.W., et al., Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5, Science, 1998, vol. 282, pp. 1907-1911.
Michael, N.L., Louie, L.G., Rohrbaugh, A.L., et al., The Role of CCR5 and CCR2 Polymorphisms in IV-1 Transmission and Disease Progression, Nat. Med., 1997, vol. 3, pp. 1160-1162.
Mummidi, S., Ahuja, S.S., Gonzalez, E., et al., Genealogy of the CCR5 Locus and Chemokine System Gene Variants Associated with Altered Rates of HIV-1 Disease Progression, Nat. Med., 1998, vol. 4, pp. 786-793.
Alkhatib, G., Combadiere, C., Broder, C.C., et al., CCCKR5: A RANTES, MIP-1?, MIP-1??Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1, Science, 1996, vol. 272, pp. 1955-1958.
Liu, R., Paxton, W.A., Choe, S., et al., Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection, Cell (Cambridge, Mass.), 1996, vol. 86, pp. 367-377.
Doranz, B.J., Rucker, J., Yi, Y., et al., A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the ?-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors, Cell (Cambridge, Mass.), 1996, vol. 85, pp. 1149-1158.
Martinson, J.J., Hong, L., Karanicolas, R., et al., Global Distribution of the CCR2-64I/CCR5-59653T HIV-1 Disease-Protective Haplotype, AIDS, 2000, vol. 31, pp. 4483-489l.
Lee, B., Doranz, B.J., Rana, S., et al., Influence of the CCR2 V64I Polymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4, J. Virol, 1998, vol. 72, pp. 7450-7458.
Kostrikis, L.G., Huang, Y., Moore, J.P., et al., A Chemokine Receptor CCR2 Allele Delays HIV-1 Disease Progression and Is Associated with a CCR5 Promoter Mutation, Nature, 1998, vol. 4, pp. 350-353.
Su, B., Jin, L., Hu, F., et al., Distribution of Two HIV-1-Resistant Polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and World Populations and Its Implication in AIDS Epidemiology, Am. J. Hum. Genet., 1999, vol. 65, pp. 1047-1053.
Su, B., Sun, G., Lu, D., et al., Distribution of Three HIV-1 Resistance-Conferring Polymorphisms (SDF1-3'A, CCR2-64I, and CCR5-?32) in Global Populations, Eur. J. Hum. Genet., 2000, vol. 8, pp. 975-979.
Ryabov, G.S., Kazennova, E.V., and Bobkov, A.F., Frequencies of the CCR2-64I and SDF1-3'A Alleles Associated with Progression of the HIV-1 Disease in Healthy Individuals from Moscow, Genetika (Moscow), 2002, vol. 38, pp. 278-280.
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Lewandowska, M., Trzeciak, W.H. & Jagodzinski, P.P. Determination of the CCR2-64I/CCR5-59653T Haplotype Linkage Disequilibrium in a Sample of Polish Population*. Russian Journal of Genetics 39, 692–694 (2003). https://doi.org/10.1023/A:1024418229233
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DOI: https://doi.org/10.1023/A:1024418229233