Abstract
Studies of C57BL/6J mice with acquired submissive behavior in a sensory contact model demonstrated increases in serotonin (5-HT) levels in the amygdaloid complex, hippocampus, the dopaminergic nuclei A11, A10, and A9, and in the caudate nucleus and hypothalamus, compared with controls, after 10 and 20 days of confrontations. Levels of the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) in most structures were significantly higher after 20 days of confrontations than after 10 days. Increases in the 5-HIAA/5-HT ratio in the cervical nuclei of the midbrain, nucleus accumbens, A9, and hypothalamus as compared with controls were seen in mice with 10 and 20 days of confrontations. Immunization of mice on days 10 and 20 of confrontations showed suppression of immune responses as compared with controls, while immune measures reached control values by 40 days of experience of defeat. Thus, experience of 10 days of defeat led to immunosuppression on a background of activation of the 5-HT system in a series of brain structures: the cervical nuclei of the midbrain, the nucleus accumbens, and A9. As confrontations continued, there were decreases in the 5-HIAA/5-HT ratio on these structures, along with a tendency for immune responses to increase.
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REFERENCES
O. V. Galkina, E. L. Al'perina, O. V. Suslyakova, and L. V. Devoino, “Serotonin and 5-hydroxyindoleacetic acid levels in brain and immunocompetent organs after immunizations,” Byull. Éksperim. Biol. Med., 110, No. 8, 178–180 (1990).
A. V. Gorbunova, “Biogenic amines in brain structures of rats of different zoosocial ranks in immobilization stress,” Byull. Éksperim. Biol. Med., 63, No. 6, 570–572 (1992).
L. V. Devoino, E. L. Al'perina, N. N. Kudryavtseva, and N. K. Popova, “Studies of the immune response in male mice with aggressive and submissive types of behavior,” Ros. Fiziol. Zh. im. I. M. Sechenova, 77, No. 12, 62–67 (1991).
L. V. Devoino, G. V. Idova, E. L. Al'perina, and M. A. Cheido, “The neurochemical apparatus of the brain – an extraimmune mechanism of psychoneuroimmunomodulation,” Vestn. RAMN, 9, 19–24 (1998).
L. V. Devoino and R. Yu. Il'yuchenok, Monoaminergic Systems in the Regulation of Immune Reactions (Serotonin, Dopamine) [in Russian], Nauka, Novosibirsk (1983).
L. B. Devoino and R. Yu. Il'yuchenok, Neurotransmitter Systems in Psychoneuroimmunomodulation: Dopamine, Serotonin, GABA, and Neuropeptides [in Russian], TsÉRIS, Novosibirsk (1993).
O. F. Eremina and L. V. Devoino, “Production of humoral antibodies in rabbits in conditions of lesioning of the nucleus of the midbrain nucleus,” Byull. Éksperim. Biol. Med., 74, No. 2, 58–60 (1973).
G. V. Idova, M. A. Cheido, and L. V. Devoino, “IgM-and IgG-rosette-formation in primary and secondary immune responses in a syngeneic spleen cell transfer system,” Zh. Mikrobiol. Épidemiol. Immunobiol., 2, 57–60 (1976).
E. A. Korneva and L. V. Khai, “The effects of lesioning of parts of the hypothalamic region on the process of immunogenesis,” Fiziol. Zh. SSSR, 49, No. 1, 42–48 (1963).
N. N. Kudryavtseva, T. G. Amstislavskaya, D. F. Avgustinovich, I. V. Bakshtanovskaya, T. V. Lipina, O. V. Gorbach, and L. A. Koryakina, “The effects of repeated experience of defeats and victories in social conflicts on the state of the serotoninergic system in the brains of male mice,” Zh. Vyssh. Nerv. Deyat., 46, No. 6, 1088–1096 (1996).
N. N. Kudryavtseva and I. V. Bakshtanovskaya, The Effects of Experience of Aggression and Submission on the State of Transmitter Systems in Various Parts of the Brain in Mice [in Russian], Preprint, Novosibirsk (1989).
S. V. Magaeva, The Immunodeficient State in Experimental Pathology of the Hippocampus [in Russian], Author's abstract of doctoral thesis, Moscow (1979).
N. K. Popova, A. V. Kulikov, D. F. Avgustinovich, and S. N. Shingantsov, “Characteristics of the serotoninergic system of the brain and anxiety in mice of the lines C57B1 and CBA,” Zh. Vyssh. Nerv. Deyat., 46, No. 2, 348–354 (1996).
V. P. Poshivalov, The Experimental Psychophysiology of Aggressive Behavior [in Russian], Nauka, Leningrad (1986).
D. C. Blanchard, G. Griebel, R. J. Rodgers, and R. J. Blanchard, “Benzodiazepines and serotonergic modulation of antipredator and conspecific defense,” Neurosci. Biobehav. Rev., 22, No. 5, 597–612 (1998).
R. J. Cross, W. H. Brooks, T. L. Roszman, and W. R. Markesbery, “Hypothalamic-immune interaction. Effect of hypophysectomy on neuroimmunomodulation,” J. Neurol. Sci., 53, No. 3, 557–566 (1982).
A. J. Cunningham, “A method of increased sensitivity for detecting single antibody-forming cells,” Nature, 207, 1106–1107 (1965).
R. S. Devi and A. Namasivayam, “Modulation of specific immunity of ventral hippocampal formation in albino rats,” J. Neuroimmunol., 33, 1–6 (1991).
L. Devoino, E. Alperina, O. Galkina, and R. Ilyutchenok, “Involvement of brain dopaminergic structures on neuroimmunomodulation,” Int. J. Neurosci., 91, No. 3–4, 213–228 (1997).
L. Devoino and G. Idova, “Influence of some drugs on the immune response, IV. Effect of serotonin, 5-hydroxytryptophan, iproniazid, and p-chlorophenylalanine on the synthesis of IgM and IgG antibodies,” Eur. J. Pharmacol., 22, 325–331 (1973).
L. Devoino, G. V. Idova, E. Alperina, and M. Cheido, “Brain neuromediator systems in the immune response control: pharmacological analysis of pre-and postsynaptic mechanisms,” Brain Res., 633, 267–274 (1994).
J. C. Jackson, R. J. Cross, W. K. Markesbery, and W. H. Brooks, “Influence of serotonin on the immune response,” Immunology, 54, 505–512 (1985).
P. J. Neveu, “Brain lateralization and immunomodulation,” Int. J. Neurosci., 70, No. 1–2, 135–143 (1993).
Y. Qui, Y. Peng, and J. Wang, “Immunoregulatory role of neurotransmitters,” Adv. Neuroimmunol., 6, 223–231 (1996).
S. Vlajkovic, S. Dugandzija-Navakovic, S. Milanovic, and B. D. Jankovic,.Int. J. Neurosci., 69, 235–250 (1993).
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Devoino, L.V., Al'perina, E.L., Podgornaya, E.K. et al. Nature of the Distribution of Serotonin and a Serotonin Metabolite in Brain Structures and the Development of Immunosuppression in Submissive Mice. Neurosci Behav Physiol 33, 473–477 (2003). https://doi.org/10.1023/A:1023463201122
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DOI: https://doi.org/10.1023/A:1023463201122