Abstract
The inclusion complexes of the carboxylate forms of 3-carboxy-(I) and 2-carboxy-phenoxathiin (II) with β-cyclodextrin were studied by bothone- and two-dimensional NMR spectroscopy. The analysis of the induced chemical shifts of theguests in the presence of different amounts of the host indicates the formation of complexes with 1:1stoichiometry and association averaged pK values of 3.75 (I) and 4.4 (II). Thequalitative analysis of cross peaks in the ROESY spectra support the inclusion of the guests in the cavitywith the substituted phenyl ring, the COO- group being in the proximity of the primary rim.
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Tintaru, A., Hillebrand, M. & Thevand, A. NMR Study of the Inclusion Complexes of Carboxy-Phenoxathiin Derivatives with β-Cyclodextrin. Journal of Inclusion Phenomena 45, 35–40 (2003). https://doi.org/10.1023/A:1023044700449
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DOI: https://doi.org/10.1023/A:1023044700449