Abstract
Chicken liver basic fatty acid binding protein (Lb-FABP) belongs to the basic-type fatty acid binding proteins, a novel group of proteins isolated from liver of different non mammalian species whose structure is not known. The structure of Lb-FABP has been solved by 1H NMR. The overall fold of Lb-FABP, common to the other proteins of the family, consists of ten antiparallel β-strands organised in two nearly ortogonal β-sheets with two alpha helices closing the protein cavity where small hydrophobic ligands can be bound. The binding specificity of the protein is not known, however, based on the high sequence and structural similarity with an orthologous protein, ileal lipid binding protein, it is suggested that bile acids may be the putative ligands.
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Bartels, C., Xia, T., Billeter, M., Güntert, P. and Wüthrich, K. (1995) J. Biomol. NMR, 5, 1-10.
Beringhelli, T., Goldoni, L., Capaldi, S., Bossi, A., Perduca, M. and Monaco, H.L. (2001) Biochemistry, 40, 12604-12611.
Börchers, T. and Spener, F. (1993) Mol. Cell. Biochem., 123, 23-27.
Bratt, T. (2000) Biochim. Biophys. Acta, 1482, 318-326.
Di Pietro, S.M., Veerkamp, J.H. and Santomè, J.A. (1999) Eur. J. Biochem., 259, 127-134.
Güntert, P., Mumenthaler, C. and Wüthrich, K. (1997) J. Mol. Biol., 273, 263-296.
Hodson, M.E. and Cistola, D.P. (1997) Biochemistry, 36, 2278-2290.
Laskowski, R.A., MacArthur, M.W., Moss, D.S. and Thornton, J.M. (1993) J. Appl. Crystallogr., 26, 283-291.
Lassen, D., Lücke, C., Kveder, M., Mesgarzadeh, A. Schmidt, J.M., Specht, B., Lezius, A., Spener, F. and Ruterjans, H. (1995) Eur. J. Biochem., 230, 266-280.
Lücke, C., Rademacher, M., Zimmerman, A., van Moerkerk, H.T.B., Veerkamp, J.H. and Rüterjans, H. (2001) Biochem J., 354, 259-266.
Lücke, C., Zhang, F., Hamilton, J.A., Sacchettini, J.C and Rüterjans, H. (2000) Eur. J. Biochem., 267, 2929-2938.
Lücke, C., Zhang, F., Rüterjans, H., Hamilton, J.A. and Sacchettini, J.C. (1996) Structure, 4, 785-800.
Ragona, L., Pusterla, F., Zetta, L., Monaco H.L. and Molinari, H. (1997) Fold. Des., 2, 281-190.
Scapin, G., Spadon, P., Pengo, L., Mammi, M., Zanotti, G. and Monaco, H.L. (1988) FEBS Lett., 240, 196-200.
Schievano, E., Mammi, S. and Peggion, E. (1999) Biopolymers, 5, 1-11.
Zhang, F., Lücke, C., Baier, L.J., Sacchettini J.C. and Hamilton J.A. (1997) J. Biomol. NMR, 9, 213-228.
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Vasile, F., Ragona, L., Catalano, M. et al. Letter to the Editor: Solution structure of chicken liver basic fatty acid binding protein. J Biomol NMR 25, 157–160 (2003). https://doi.org/10.1023/A:1022277727303
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DOI: https://doi.org/10.1023/A:1022277727303