Skip to main content
SpringerLink
Log in

Proline-Specific Endopeptidases

  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract

Prolyl endopeptidases, or post-proline-cleaving enzymes, are the specific endopeptidases that hydrolyze peptide substrates at the carbonyl of the internal Pro residue. All the currently known prolyl endopeptidases from animals, microorganisms, fungi, and plants as well as the post-proline-cleaving enzymes that do not exhibit the strict specificity to Pro are reviewed. The data on their physicochemical and catalytic properties, substrate specificity, inhibitors, sequences, and three-dimensional structures are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. MEROPS, http://www.academicpress.com/merops/.

  2. Barrett, A.J., Rawlings, N.D., and Woessner, J.F., Handbook of Proteolytic Enzymes, New York: Academic, 1998.

    Google Scholar 

  3. Rawlings, N.D. and Barrett, A.J., Biochem. J., 1993, vol.290, pp. 205–218.

    Google Scholar 

  4. Barrett, A.J. and Rawlings, N.D., Arch. Biochem. Biophys., 1995, vol. 318, pp. 247–250.

    Google Scholar 

  5. Walter, R., Simmons, W.H., and Yoshimoto, T., Mol. Cell. Biochem., 1980, vol. 30, pp. 111–127.

    Google Scholar 

  6. Walter, R., Shlank, H., Glass, J.D., Schwartz, I.L., and Kerenyi, T.D., Science, 1971, vol. 173, pp. 827–829.

    Google Scholar 

  7. Hauzer, K., Servitova, L., Barth, T., and Jost, K., Collect. Czech. Chem. Commun., 1982, vol. 47, pp. 1139–1148.

    Google Scholar 

  8. Walter, R., Biochim. Biophys. Acta, 1976, vol. 422, pp.138–158.

    Google Scholar 

  9. Yoshimoto, T., Ogita, K., Walter, R., Koida, M., and Tsuru, D., Biochim. Biophys. Acta, 1979, vol. 569, pp.184–192.

    Google Scholar 

  10. Kato, T., Okada, M., and Nagatsu, T., Mol. Cell. Biochem., 1980, vol. 32, pp. 117–121.

    Google Scholar 

  11. Goossens, F., De Meester, I., Vanhoof, G., and Scharpe, S., J. Clin. Chem., Clin. Biochem., 1996, vol. 34, pp. 17–22.

    Google Scholar 

  12. Brzezinska-Slebodzinska, E. and Adamczyk, J., Acta Biochim. Pol., 1979, vol. 26, pp. 407–416.

    Google Scholar 

  13. Knisatschek, H. and Bauer, K., J. Biol. Chem., 1979, vol. 254, pp. 10 936–10 943.

    Google Scholar 

  14. Rupnow, J.H., Taylor, W.L., and Dixon, J.E., Biochemistry, 1979, vol. 18, pp. 1206–1212.

    Google Scholar 

  15. Andrews, P.C., Hines, C.M., and Dixon, J.E., Biochemistry, 1980, vol. 19, pp. 5494–5500.

    Google Scholar 

  16. Andrews, P.C., Minth, C.D., and Dixon, J.E., J. Biol. Chem., 1982, vol. 257, pp. 5861–5865.

    Google Scholar 

  17. Hersh, L.B. and McKelvy, J.F., Brain Res., 1979, vol.168, pp. 553–564.

    Google Scholar 

  18. Hersh, L.B., J. Neurochem., 1981, vol. 37, pp. 172–178.

    Google Scholar 

  19. Yoshimoto, T., Simmons, W.H., Kita, T., and Tsuru, D., J. Biochem. (Tokyo), 1981, vol. 90, pp. 325–334.

    Google Scholar 

  20. Yoshimoto, T., Nishimura, T., Kita, T., and Tsuru, D., J. Biochem. (Tokyo), 1983, vol. 94, pp. 1179–1190.

    Google Scholar 

  21. Schonlein, C., Heins, J., and Barth, A., Biol. Chem. Hoppe-Seyler, 1990, vol. 371, pp. 1159–1164.

    Google Scholar 

  22. Browne, P. and O'Cuinn, G., Eur. J. Biochem., 1983, vol.137, pp. 75–87.

    Google Scholar 

  23. Kalwant, S. and Porter, A.G., Biochem. J., 1991, vol.276, pp. 237–244.

    Google Scholar 

  24. Oliveira, E.B., Martins, A.R., and Camargo, A.C., Biochemistry, 1976, vol. 15, pp. 1967–1974.

    Google Scholar 

  25. Orlowski, M., Wilk, E., Pearce, S., and Wilk, S., J. Neurochem., 1979, vol. 33, pp. 461–469.

    Google Scholar 

  26. Yokosawa, H., Miyata, M., Sawada, H., and Ishii, S., J. Biochem. (Tokyo), 1983, vol. 94, pp. 1067–1076.

    Google Scholar 

  27. Yoshida, K., Inaba, K., Ohtake, H., and Morisawa, M., Dev. Growth Differ., 1999, vol. 41, pp. 217–225.

    Google Scholar 

  28. Swanson, A.A., Davis, R.M., and McDonald, J.K., Curr. Eye Res., 1984, vol. 3, pp. 659–661.

    Google Scholar 

  29. Hauzer, K., Jost, K., Low, M., and Polgar, L., Acta Biochim. Biophys. Acad. Sci. Hung., 1984, vol. 19, pp. 165–168.

    Google Scholar 

  30. Moriyama, A., Nakanishi, M., and Sasaki, M., J. Biochem. (Tokyo), 1988, vol. 104, pp. 112–117.

    Google Scholar 

  31. Rosen, J., Tomkinson, B., Pettersson, G., and Zetterqvist, O., J. Biol. Chem., 1991, vol. 266, pp. 3824–3834.

    Google Scholar 

  32. Nozaki, Y., Sato, N., Iida, T., Hara, K., Fukuyama, K., and Epstein, W.L., J. Cell. Biochem., 1992, vol. 49, pp.296–303.

    Google Scholar 

  33. Kusuhara, M., Hachisuka, H., Nakano, S., and Sasai, Y., J. Dermatol. Sci., 1993, vol. 6, pp. 138–145.

    Google Scholar 

  34. Goossens, F., De Meester, I., Vanhoof, G., Hendriks, D., Vriend, G., and Scharpe, S., Eur. J. Biochem., 1995, vol.233, pp. 432–441.

    Google Scholar 

  35. Cunningham, D.F. and O'Connor, B., Int. J. Biochem., Cell. Biol., 1998, vol. 30, pp. 99–114.

    Google Scholar 

  36. Cunningham, D.F. and O'Connor, B., Biochim. Biophys. Acta, 1997, vol. 1343, pp. 160–186.

    Google Scholar 

  37. Szeltner, Z., Renner, V., and Polgar, L., J. Biol. Chem., 2000, vol. 275, pp. 15 000–15 005.

    Google Scholar 

  38. Yoshimoto, T., Fischl, M., Orlowski, R.C., and Walter, R., J. Biol. Chem., 1978, vol. 253, pp. 3708–3716.

    Google Scholar 

  39. Wilk, S. and Orlowski, M., J. Neurochem., 1983, vol. 41, pp. 69–75.

    Google Scholar 

  40. Bakker, A.V., Daffeh, J., Jung, S., Vincent, L.A., Nagel, A.A., Spencer, R.W., Vinick, F.J., and Faraci, W.S., Bioorg. Med. Chem. Lett., 1991, vol. 1, pp. 585–590.

    Google Scholar 

  41. Steinmetzer, T., Silberring, J., Mrestani-Klaus, C., Fittkau, S., Barth, A., and Demuth, H.U., J. Enzym. Inhib., 1993, vol. 7, pp. 77–85.

    Google Scholar 

  42. Tsuru, D., Yoshimoto, T., Koriyama, N., and Furukawa, S., J. Biochem., 1988, vol. 104, pp. 568–580.

    Google Scholar 

  43. Koida, M. and Walter, R., J. Biol. Chem., 1976, vol. 251, pp. 7593–7599.

    Google Scholar 

  44. Polgar, L., Eur. J. Biochem., 1991, vol. 197, pp. 441–447.

    Google Scholar 

  45. Walter, R. and Yoshimoto, T., Biochemistry, 1978, vol.17, pp. 4139–4144.

    Google Scholar 

  46. Noula, C., Kokotos, G., Barth, T., and Tzougraki, C., J. Pept. Res., 1997, vol. 49, pp. 46–51.

    Google Scholar 

  47. Kaspari, A., Diefenthal, T., Grosche, G., Schierhorn, A., and Demuth, H.U., Biochim. Biophys. Acta, 1996, vol.1293, pp. 147–153.

    Google Scholar 

  48. Yoshimoto, T., Orlowski, R.C., and Walter, R., Biochemistry, 1977, vol. 16, pp. 2942–2948.

    Google Scholar 

  49. Rennex, D., Hemmings, B.A., Hofsteenge, J., and Stone, S.R., Biochemistry, 1991, vol. 30, pp. 2195–2203.

    Google Scholar 

  50. Vanhoof, G., Goossens, F., Hendriks, L., De Meester, I., Hendriks, D., Vriend, G., van Broeckhoven, C., and Scharpe, S., Gene, 1994, vol. 149, pp. 363–366.

    Google Scholar 

  51. Yoshimoto, T., Miyazaki, K., Haraguchi, N., Kitazono, A., Kabashima, T., and Ito, K., Biol. Pharm. Bull., 1997, vol. 20, pp. 1047–1050.

    Google Scholar 

  52. Ishino, T., Ohtsuki, S., Homma, Ki., and Natori, S., J. Biochem., 1998, vol. 123, pp. 540–545.

    Google Scholar 

  53. Fulop, V., Bocskei, Z., and Polgar, L., Cell, 1998, vol. 94, pp. 161–170.

    Google Scholar 

  54. Bocskei, Z., Fuxreiter, M., Naray-Szabo, G., Szabo, E., and Polgar, L., Acta Crystallogr., Sect. D: Biol. Crystallogr., 1998, vol. 54, pp. 1414–1415.

    Google Scholar 

  55. Mizutani, S., Sumi, S., Suzuki, O., Narita, O., and Tomoda, Y., Biochim. Biophys. Acta, 1984, vol. 786, pp.113–117.

    Google Scholar 

  56. Sumi, S., Mizutani, S., Narita, O., and Tomoda, Y., Nippon Sanka Fujinka Gakkai Zasshi, 1984, vol. 36, pp.1943–1951.

    Google Scholar 

  57. Zolfaghari, R., Baker, C.R., Canizaro, P.C., Feola, M., Amirgholami, A., and Behal, F.J., Enzyme, 1986, vol. 36, pp. 165–178.

    Google Scholar 

  58. Matsubara, Y., Ono, T., Tsubuki, S., Irie, S., and Kawashima, S., Eur. J. Biochem., 1998, vol. 252, pp. 178–183.

    Google Scholar 

  59. O'Leary, R.M. and O'Connor, B., Eur. J. Biochem., 1995, vol. 227, pp. 277–283.

    Google Scholar 

  60. O'Leary, R.M., Gallagher, S.P., and O'Connor, B., Int. J. Biochem. Cell. Biol., 1996, vol. 28, pp. 441–449.

    Google Scholar 

  61. Checler, F., Vincent, J.P., and Kitabgi, P., J. Biol. Chem., 1986, vol. 261, pp. 11 274–11 281.

    Google Scholar 

  62. Dauch, P., Vincent, J.P., and Checler, F., Eur. J. Biochem., 1991, vol. 202, pp. 269–276.

    Google Scholar 

  63. Millican, P.E., Kenny, A.J., and Turner, A.J., Biochem. J., 1991, vol. 276, pp. 583–591.

    Google Scholar 

  64. Dahms, P. and Mentlein, R., Eur. J. Biochem., 1992, vol.208, pp. 145–154.

    Google Scholar 

  65. Barelli, H., Vincent, J.P., and Checler, F., Eur. J. Biochem., 1993, vol. 211, pp. 79–90.

    Google Scholar 

  66. Vincent, B., Vincent, J.P., and Checler, F., Brain Res., 1996, vol. 709, pp. 51–58.

    Google Scholar 

  67. Serizawa, A., Dando, P.M., and Barrett, A.J., J. Biol. Chem., 1995, vol. 270, pp. 2092–2098.

    Google Scholar 

  68. Lian, W., Chen, G., Wu, D., Brown, C.K., Madauss, K., Hersh, L.B., and Rodgers, D.W., Acta Crystallogr., Sect. D: Biol. Crystallogr., 2000, vol. 56, pp. 1644–1646.

    Google Scholar 

  69. Brown, C.K., Madauss, K., Lian, W., Beck, M.R., Tolbert, W.D., and Rodgers, D.W., Proc. Natl. Acad. Sci. USA, 2001, vol. 98, pp. 3127–3132.

    Google Scholar 

  70. Quinto, B.M., Juliano, M.A., Hirata, I., Carmona, A.K., Juliano, L., and Casarini, D.E., Int. J. Biochem. Cell. Biol., 2000, vol. 32, pp. 1161–1172.

    Google Scholar 

  71. Prasad, C. and Peterkofsky, A., J. Biol. Chem., 1976, vol.251, pp. 3229–3234.

    Google Scholar 

  72. Kato, T., Nakano, T., Kojima, K., Nagatsu, T., and Sakakibara, S., J. Neurochem., 1980, vol. 35, pp. 527–535.

    Google Scholar 

  73. Wilk, S., Life Sci., 1983, vol. 33, pp. 2149–2157.

    Google Scholar 

  74. Mentlein, R. and Dahms, P., J. Neurochem., 1994, vol.62, pp. 27–36.

    Google Scholar 

  75. Maes, M., Monteleone, P., Bencivenga, R., Goossens, F., Maj, M., van West, D., Bosmans, E., and Scharpe, S., Psychoneuroendocrinology, 2001, vol. 26, pp. 17–26.

    Google Scholar 

  76. Yoshimoto, T., Kado, K., Matsubara, F., Koriyama, N., Kaneto, H., and Tsuru, D., J. Pharmacobiodyn., 1987, vol. 10, pp. 730–735.

    Google Scholar 

  77. Szwajcer-Dey, E., Rasmussen, J., Meldal, M., and Breddam, K., J. Bacteriol., 1992, vol. 174, pp. 2454–2459.

    Google Scholar 

  78. Habibi-Najafi, M.B. and Lee, B.H., J. Dairy Sci., 1994, vol. 77, pp. 385–392.

    Google Scholar 

  79. Kabashima, T., Fujii, M., Meng, Y., Ito, K., and Yoshimoto, T., Arch. Biochem. Biophys., 1998, vol. 358, pp.141–148.

    Google Scholar 

  80. Yoshimoto, T., Sattar, A.K., Hirose, W., and Tsuru, D., J. Biochem. (Tokyo), 1988, vol. 104, pp. 622–627.

    Google Scholar 

  81. Sattar, A.K., Yamamoto, N., Yoshimoto, T., and Tsuru, D., J. Biochem. (Tokyo), 1990, vol. 107, pp. 256–261.

    Google Scholar 

  82. Yoshimoto, T., Walter, R., and Tsuru, D., J. Biol. Chem., 1980, vol. 255, pp. 4786–4792.

    Google Scholar 

  83. Heins, J., Welker, P., Schonlein, C., Born, I., Hartrodt, B., Neubert, K., Tsuru, D., and Barth, A., Biochim. Biophys. Acta, 1988, vol. 954, pp. 161–169.

    Google Scholar 

  84. Chevallier, S., Goeltz, P., Thibault, P., Banville, D., and Gagnon, J., J. Biol. Chem., 1992, vol. 267, pp. 8192–8199.

    Google Scholar 

  85. Kanatani, A., Yoshimoto, T., Kitazono, A., Kokubo, T., and Tsuru, D., J. Biochem., 1993, vol. 113, pp. 790–796.

    Google Scholar 

  86. Kuwabara, T., FEBS Lett., 1992, vol. 300, pp. 127–130.

    Google Scholar 

  87. Kuwabara, T. and Suzuki, K., Plant Cell Physiol., 1994, vol. 35, pp. 665–675.

    Google Scholar 

  88. Sharma, K.K. and Ortwerth, B.J., Exp. Eye Res., 1994, vol. 59, pp. 107–115.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chair of Natural Compounds Chemistry, Chemistry Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899, Russia

    D. V. Besedin & G. N. Rudenskaya

Authors
  1. D. V. Besedin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. N. Rudenskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. V. Besedin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Besedin, D.V., Rudenskaya, G.N. Proline-Specific Endopeptidases. Russian Journal of Bioorganic Chemistry 29, 1–17 (2003). https://doi.org/10.1023/A:1022221400750

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022221400750

Search

Navigation