Abstract
A convenient one-pot synthesis of stable phosphorus ylides by the condensation of triphenylphosphine with dialkyl acetylenedicarboxylate and CH acids, such as penta-2,4-dione or diethyl propane-1,3-dioate, in the presence of β-cyclodextrin as a catalyst (to increase the solubility of the reactants in water) without using toxic organic solvents was proposed. This methodology is of interest due to the use of water as a solvent, thus minimizing such factors as the cost, operational hazards, and environmental pollution.
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Islami, M.R., Yavari, I., Tikdari, A.M. et al. A practical method for synthesis of stable phosphorus ylides in aqueous media. Russian Chemical Bulletin 51, 2244–2247 (2002). https://doi.org/10.1023/A:1022187419289
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DOI: https://doi.org/10.1023/A:1022187419289