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Effects of Acute and Chronic Caffeine Intake on Intravenous Self-Administration of Morphine in Two Rat Strains

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Abstract

Effects of acute and chronic caffeine intake on the level and pattern of morphine self-administration behavior in WAG/G and Fisher-344 rats were studied. Both acute and chronic caffeine intake decreased morphine self-administration only in WAG/G rats, which attested to increased sensitivity of these rats to reinforcing effects of morphine. Possible relationship between the observed changes and increased anxiety in rats receiving caffeine is discussed.

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Authors and Affiliations

  1. Institute of Biomedical Engineering, Russia

    S. K. Sudakov, I. P. Papazov, Yu. V. Lyupina, O. F. Medvedeva, I. V. Figurina & I. V. Rusakova

  2. Institute of Diagnostics and Prophylaxis of Socially Dangerous Diseases, Moscow

    S. K. Sudakov, I. P. Papazov, Yu. V. Lyupina, O. F. Medvedeva, I. V. Figurina & I. V. Rusakova

Authors
  1. S. K. Sudakov
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  2. I. P. Papazov
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  3. Yu. V. Lyupina
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  4. O. F. Medvedeva
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  5. I. V. Figurina
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  6. I. V. Rusakova
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Sudakov, S.K., Papazov, I.P., Lyupina, Y.V. et al. Effects of Acute and Chronic Caffeine Intake on Intravenous Self-Administration of Morphine in Two Rat Strains. Bulletin of Experimental Biology and Medicine 134, 400–402 (2002). https://doi.org/10.1023/A:1021980919850

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  • DOI: https://doi.org/10.1023/A:1021980919850

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