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6α-Methyl-16α,17α-Cyclohexane Progesterone and Progesterone Inhibit Growth of Doxorubicin-Sensitive MCF-7 and HeLa Tumor Cells

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Abstract

Temporal and concentration dependencies of the effects of gestagens (6α-methylpentarane and progesterone) and cytostatic doxorubicin on proliferation of MCF-7 and HeLa tumor cells was studied using 3H-thymidine test. Gestagens produced the maximum inhibitory effect of on cell proliferation in a concentration of 10-5 M; the effect developed on day 6 of incubation. 6 α-Methylpentarane in a concentration of 10-8 inhibited proliferation of HeLa cells more effectively than progesterone (p<0.05). In experiments with combined treatment of doxorubicin-sensitive MCF-7 and HeLa cells, progesterone in a concentration of 10-7 M attenuated the cytostatic effect of doxorubicin (p<0.05), while 6α-methylpentarane in the studied concentrations did not modulate it.

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Authors and Affiliations

  1. Department of Molecular Pharmacology and Radiobiology, Biomedical Faculty, Russian State Medical University, Russia

    N. L. Shimanovskii, A. V. Semeikin, T. A. Fedotcheva, A. V. Fedosov, A. V. Kamernitskii & I. S. Levina

  2. N. D. Zelinskii Institute of Organic Chemistry, Group for Investigation of Steroid and Oxylipin Chemistry, Russia

    N. L. Shimanovskii, A. V. Semeikin, T. A. Fedotcheva, A. V. Fedosov, A. V. Kamernitskii & I. S. Levina

Authors
  1. N. L. Shimanovskii
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  2. A. V. Semeikin
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  3. T. A. Fedotcheva
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  4. A. V. Fedosov
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  5. A. V. Kamernitskii
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  6. I. S. Levina
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Shimanovskii, N.L., Semeikin, A.V., Fedotcheva, T.A. et al. 6α-Methyl-16α,17α-Cyclohexane Progesterone and Progesterone Inhibit Growth of Doxorubicin-Sensitive MCF-7 and HeLa Tumor Cells. Bulletin of Experimental Biology and Medicine 134, 385–388 (2002). https://doi.org/10.1023/A:1021972618033

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  • DOI: https://doi.org/10.1023/A:1021972618033

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