The effects of nine new pregnane steroids containing substituents in the 16α,17α- and/or 3-, 6-, and 19-positions of the steroid framework on the viability of HeLa cervical cancer cells were studied. It was shown that the 6-oximes of 3-keto- and 3-hydroxy-4-dehydrosteroids with a 16α,17α-cyclohexane substituent and 3-keto-4-dehydrosteroids with a 16α,17α-phenylcyclopropane substituent reduced the viability of the cell culture. Compound K1047 had the highest cytostatic effect and was promising as a potential hormonal antitumor agent.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 6, pp. 9 – 13, June, 2014.
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Semeikin, A.V., Fedotcheva, T.A., Levina, I.S. et al. Synthesis and Cytostatic Activity of some Pregna-D′-Pentaranes on HeLa Cell Culture. Pharm Chem J 48, 363–367 (2014). https://doi.org/10.1007/s11094-014-1111-x
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DOI: https://doi.org/10.1007/s11094-014-1111-x