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Conjugates of Aberrant Gangliosides in Antiglioma Vaccine: Toxicological Assay

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Abstract

We studied sterility and toxicity of vaccine LS1 containing aberrant gangliosides isolated from brain bioptates of 48 patients with gliomas of different malignancy and covalently bound to keyhole limpet hemocyanin. The vaccine was safe. This preparation produced no side effects in experimental animals. Our findings substantiated the necessity of father development of this method of vaccination. The vaccine should undergo clinical tests in patients with malignant gliomas.

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Authors and Affiliations

  1. Institute of Pathological Anatomy, University of Bari, Italy

    V. Lombardi, R. Shnaar, B. Minev, R. Misasi, Kh. Gitstsi, M. Sorice & A. Troncone

  2. Johns Hopkins Medical School, Baltimore, USA

    V. Lombardi, R. Shnaar, B. Minev, R. Misasi, Kh. Gitstsi, M. Sorice & A. Troncone

  3. University of California, La Jolla, USA

    V. Lombardi, B. Minev, R. Misasi, Kh. Gitstsi, M. Sorice & A. Troncone

  4. Institute of Experimental Medicine and Pathology, University of Rome, La Sapienca, Italy

    V. Lombardi, R. Shnaar, R. Shnaar, B. Minev, R. Misasi, Kh. Gitstsi, M. Sorice & A. Troncone

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  1. V. Lombardi
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  2. R. Shnaar
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  3. B. Minev
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  4. R. Misasi
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  5. Kh. Gitstsi
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  6. M. Sorice
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  7. A. Troncone
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Lombardi, V., Shnaar, R., Minev, B. et al. Conjugates of Aberrant Gangliosides in Antiglioma Vaccine: Toxicological Assay. Bulletin of Experimental Biology and Medicine 134, 363–365 (2002). https://doi.org/10.1023/A:1021908331236

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  • DOI: https://doi.org/10.1023/A:1021908331236

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