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Synthesis of thieno[3,4-d]pyrimidines by the reactions of 3-amino-4-carbamoylthiophene derivatives with 1,3-dicarbonyl compounds

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Abstract

The reactions of ethyl 3-amino-4-carbamoyl-5-methylthiophene-2-carboxylate with 1,3-dicarbonyl compounds were studied. During the reactions, the corresponding ketone is eliminated to give ethyl 5-methyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxylates.

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Authors and Affiliations

  1. State Scientific Center of the Russian Federation “Organic Intermediate Products and Dyes Institute”, 1 ul. Bol"shaya Sadovaya, 103787, Moscow, Russian Federation

    S. A. Ryndina, A. V. Kadushkin & V. G. Granik

  2. Center of Drug Chemistry, All-Russian Research Chemical Pharmaceutical Institute, 7 Zubovskaya pl., 119815, Moscow, Russian Federation

    N. P. Solov"eva

Authors
  1. S. A. Ryndina
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  2. A. V. Kadushkin
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  3. N. P. Solov"eva
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  4. V. G. Granik
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Ryndina, S.A., Kadushkin, A.V., Solov"eva, N.P. et al. Synthesis of thieno[3,4-d]pyrimidines by the reactions of 3-amino-4-carbamoylthiophene derivatives with 1,3-dicarbonyl compounds. Russian Chemical Bulletin 51, 1879–1885 (2002). https://doi.org/10.1023/A:1021356603146

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