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Synthesis of 12-aryl-1-oxo-1,2,3,4,5,12-hexahydroindolo-[2,1-b]quinazoline-6-carbonitriles by recyclization of 11-aryl-1-oxo-2,3,4,5,10b,11-hexahydro-1H-indolo[2,3-b]quinoline-10b-carbonitriles

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Abstract

A general and convenient method for the synthesis of 12-aryl-1-oxo-1,2,3,4,5,12-hexahydroindolo[2,1-b]quinazoline-6-carbonitriles was proposed. The method is based on the recyclization of 11-aryl-1-oxo-2,3,4,5,10b,11-hexahydro-1H-indolo[2,3-b]quinoline-10b-carbonitriles. The structure of 12-(3-methoxyphenyl)-8-methyl-1-oxo-1,2,3,4,5,12-hexahydroindolo[2,1-b]quinazoline-6-carbonitrile was studied by X-ray diffraction analysis.

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Authors and Affiliations

  1. Russian Academy of Sciences, N. D. Zelinsky Institute of Organic Chemistry, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    B. V. Lichitsky, D. V. Kozhinov, L. G. Vorontsova, A. A. Dudinov & M. M. Krayushkin

  2. Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    Z. A. Starikova

Authors
  1. B. V. Lichitsky
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  2. D. V. Kozhinov
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  3. L. G. Vorontsova
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  4. Z. A. Starikova
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  5. A. A. Dudinov
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  6. M. M. Krayushkin
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Lichitsky, B.V., Kozhinov, D.V., Vorontsova, L.G. et al. Synthesis of 12-aryl-1-oxo-1,2,3,4,5,12-hexahydroindolo-[2,1-b]quinazoline-6-carbonitriles by recyclization of 11-aryl-1-oxo-2,3,4,5,10b,11-hexahydro-1H-indolo[2,3-b]quinoline-10b-carbonitriles. Russian Chemical Bulletin 51, 1869–1874 (2002). https://doi.org/10.1023/A:1021352502237

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  • DOI: https://doi.org/10.1023/A:1021352502237

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