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Simple synthesis of alkyl 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxylates from 5-acetyl-4-aminopyrimidines

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Abstract

A method for the synthesis of methyl and ethyl 2-R1-4-R2-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxylates was proposed. The method is based on condensation of 2-R1-6-R2-5-acetyl-4-aminopyrimidines with ethyl oxalate in the presence of MeONa or EtONa. Products of the Friedländer self-condensation of the starting pyrimidines were also obtained.

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Authors and Affiliations

  1. Russian Academy of Sciences, N. D. Zelinsky Institute of Organic Chemistry, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. V. Komkov & V. A. Dorokhov

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  1. A. V. Komkov
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  2. V. A. Dorokhov
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Komkov, A.V., Dorokhov, V.A. Simple synthesis of alkyl 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxylates from 5-acetyl-4-aminopyrimidines. Russian Chemical Bulletin 51, 1875–1878 (2002). https://doi.org/10.1023/A:1021304619076

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