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Modelling Dynamics of Amperometric Biosensors in Batch and Flow Injection Analysis

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Abstract

A mathematical model of amperometric biosensors has been developed. The model is based on non-stationary diffusion equations containing a non-linear term related to Michaelis–Menten kinetic of the enzymatic reaction. Using digital simulation, the influence of the substrate concentration as well as maximal enzymatic rate on the biosensor response was investigated. The digital simulation was carried out using the finite difference technique. The model describes the biosensor action in batch and flow injection regimes.

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Authors and Affiliations

  1. Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, 2600, Vilnius, Lithuania

    R. Baronas & F. Ivanauskas

  2. Institute of Biochemistry, Mokslininku 12, 2600, Vilnius, Lithuania

    J. Kulys

Authors
  1. R. Baronas
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  2. F. Ivanauskas
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  3. J. Kulys
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Baronas, R., Ivanauskas, F. & Kulys, J. Modelling Dynamics of Amperometric Biosensors in Batch and Flow Injection Analysis. Journal of Mathematical Chemistry 32, 225–237 (2002). https://doi.org/10.1023/A:1021202611359

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  • DOI: https://doi.org/10.1023/A:1021202611359

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