Abstract
Baseline external respiration and gas exchange values, as well as ventilatory thresholds and sensitivity to the O2 and CO2 stimuli in hypoxic and hypercapnic tests, were measured 1 h before and after a session of intermittent normobaric hypoxia (INH) (six repetitions with a 5-min inhalation of a gas mixture (10% O2) alternating with a 3-min inhalation of atmospheric air). After an INH session, the background CO2 level in the lungs increased by 10%. In the hypercapnic test, the actuation threshold of the ventilatory response did not change, whereas ventilatory sensitivity increased. The maximal pulmonary ventilation and the corresponding critical CO2 level in the lungs also increased at the end of the test. In the hypoxic test, the ventilatory response occurred at a decreased level of blood oxygenation after an INH session, the pulmonary ventilation level being decreased and the CO2 content in the lungs being increased at the end of the test. The data obtained evidence the maintenance of changed gas homeostasis for 1 h after an INH session. In this process, control of respiration was effected, with the hypoxic drive being weakened and the peripheral chemoreceptor sensitivity being decreased. The hypercapnic drive also increased, which may be determined by readjustment in the central mechanisms of respiratory regulation.
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Krivoshchekov, S.G., Divert, G.M. & Divert, V.E. Effect of Short-Term Intermittent Normobaric Hypoxia on the Regulation of External Respiration in Humans. Human Physiology 28, 676–681 (2002). https://doi.org/10.1023/A:1021196105213
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DOI: https://doi.org/10.1023/A:1021196105213