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Effects of Muramyl Dipeptide Glycosides on Lymphocyte Proliferation and Production of Interleukin-2

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Abstract

We studied the effect of new muramyl dipeptide glycosides with different structure of aglycon and configuration glycoside bond on spontaneous and mitogen-induced proliferation of mouse splenocytes and production of interleukin-2 by these cells. Biological activity of muramyl dipeptide beta-glycosides with aliphatic, carbocyclic, adamantile, and phenol aglycons is higher than that of the original compound, while alpha-glycosylation decreases the immunostimulating effect of this glycopeptide.

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Authors and Affiliations

  1. Laboratory of Cell Immunopathology and Biotechnology, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow

    O. V. Kalyuzhin, A. E. Zemlyakov, E. V. Kalyuzhina, M. V. Shkalev & M. V. Nelyubov

  2. Department of Organic Chemistry, V. I. Vernadskii Tavrian National University, Simferopol

    O. V. Kalyuzhin, A. E. Zemlyakov, E. V. Kalyuzhina, M. V. Shkalev & M. V. Nelyubov

Authors
  1. O. V. Kalyuzhin
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  2. A. E. Zemlyakov
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  3. E. V. Kalyuzhina
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  4. M. V. Shkalev
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  5. M. V. Nelyubov
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Kalyuzhin, O.V., Zemlyakov, A.E., Kalyuzhina, E.V. et al. Effects of Muramyl Dipeptide Glycosides on Lymphocyte Proliferation and Production of Interleukin-2. Bulletin of Experimental Biology and Medicine 134, 161–164 (2002). https://doi.org/10.1023/A:1021140432374

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  • DOI: https://doi.org/10.1023/A:1021140432374

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