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Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2/neu Mice

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Abstract

Female transgenic FVB/N mice carrying the breast cancer gene HER-2/neu received epithalon (Ala-Glu-Asp-Gly) in a dose of 1 mg subcutaneously 5 times a week to from the 2nd month of life to death. Epithalon prolonged the average and maximum lifetimes of mice by 13.5 (p<0.05) and 13.9%, respectively. The peptide prolonged the average lifetime of animals without neoplasms (by 34.2%, p<0.05). Epithalon decelerated the development of age-related disturbances in reproductive activity and suppressed the formation of neoplasms. The peptide decreased the incidence of breast adenocarcinomas, lungs metastases (by 1.6 times, p<0.05), and multiple tumors (by 2 times). Epithalon 3.7-fold increased the number of mice without breast tumors (p<0.05), while the number of animals with 6 or more breast tumors decreased by 3 times (p<0.05). Epithalon prolonged the lifetime of mice with breast tumors by 1.4 times (p<0.05). These results indicate that Epithalon possesses geroprotective activity and inhibits breast carcinogenesis in transgenic mice, which is probably related to suppression of HER-2/neu expression.

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Authors and Affiliations

  1. Department of Carcinogenesis and Oncogerontology, N. N. Petrov Institute of Oncology, Russian Ministry of Health, St. Petersburg

    V. N. Anisimov, V. Kh. Khavinson, I. N. Alimova, A. V. Semchenko & A. I. Yashin

  2. St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, Russia

    V. N. Anisimov, V. Kh. Khavinson, I. N. Alimova, A. V. Semchenko & A. I. Yashin

  3. Max Planck Institute for Demographic Research of Society, Rostock, Germany

    V. N. Anisimov, V. Kh. Khavinson, I. N. Alimova, A. V. Semchenko & A. I. Yashin

Authors
  1. V. N. Anisimov
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  2. V. Kh. Khavinson
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  3. I. N. Alimova
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  4. A. V. Semchenko
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  5. A. I. Yashin
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Anisimov, V.N., Khavinson, V.K., Alimova, I.N. et al. Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2/neu Mice. Bulletin of Experimental Biology and Medicine 134, 187–190 (2002). https://doi.org/10.1023/A:1021104819170

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  • DOI: https://doi.org/10.1023/A:1021104819170

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