Skip to main content
SpringerLink
Log in

Extrinsic Neural Regulation of Antroduodenal Motor Activity in Preterm Infants

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

This study was designed to assess whether extrinsic neural regulation of antroduodenal motor function is present in preterm neonates. Antroduodenal motor patterns were recorded in 48 infants during fasting and after a 10 ml/kg/15 min orograstric feeding. Plasma concentrations of pancreatic polypeptide were determined before and after each feeding. Of 48 infants, 24 had adult like duodenal motor responses to feeding, and they released pancreatic polypeptide postprandially. When 18 of these 24 infants were given atropine, their heart rates increased. Feedings, however, now failed to trigger adultlike duodenal motor responses or postprandial release of pancreatic polypeptide. Those 24 infants who lacked adultlike responses failed to release pancreatic polypeptide postprandially. When a subset of 10 of these infants was given atropine, feedings failed to trigger adultlike motor responses or release of pancreatic polypeptide. We conclude that extrinsic neural regulation of duodenal motor patterns is present in only about half of preterm infants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Ehrenkranz RA, Younes N, Lemons JA, Fanaroff AA, Donovan EF, Wright LL, Katsikiotis V, Tyson JE, Oh W, Shankaran S, Bauer CR, Korones SB, Stoll BJ, Stevenson DK, Papile LA: Longitudinal growth of hospitalized very low birth weight infants. Pediatrics 104:280–289, 1999

    Google Scholar 

  2. Bisquera J, Berseth CL: Effect of feeding volume on maturation of gastrointestinal function in preterm infants. Gastroenterol 120(supp 1):A264, 2001

    Google Scholar 

  3. Schanler RJ, Shulman RJ, Lau C, Smith EO, Heitkemper MM: Feeding strategies for premature infants: randomized trial of gastrointestinal priming and tube feeding method. Pediatrics 103:434–439, 1999

    Google Scholar 

  4. A-Tawil Y, Berseth C: Gestational and postnatal maturation of duodenal motor responses to intragastric feeding. J Pediatr 129:374–381, 1996

    Google Scholar 

  5. deVille K, Baker JH, Al Tawil Y, Berseth CL: Motor responses and gastric emptying in preterm infants fed formula with varying concentrations and rates of infusion. Am J Clin Nutr 68:103–108, 1998

    Google Scholar 

  6. Paje V, Berseth CL: The presence of an immature duodenal motor response to feeding in preterm infants predicts a delay in achieving full enteral feeding. Pediatr Res 47:167A, 2000

    Google Scholar 

  7. Chung SA, Greenberg GR, Diamant NE: Relationship of postprandial motilin, gastrin, and pancreatic polypeptide release to intestinal motility during vagal interruption. Can J Physiol Pharmacol 70:1148–1153, 1992

    Google Scholar 

  8. Bysschaert M, Donkier J, Dive J, Ketelslagers J, Lambert A: Gastric acid and pancreatic polypeptide responses to sham feeding are impaired in diabetic subjects with autonomic neuropathy. Diabetes 34:1181–1185, 1985

    Google Scholar 

  9. Glasbrenner B, Dominguez-Munoz E, Riepl RL, Vetsi A, Malfertheiner P: Cholecystokinen and pancreatic polypeptide release in diabetic patients with and without neuropathy. Dig Dis Sci 40:406–411, 1995

    Google Scholar 

  10. Camilleri M, Balm RK, Low PA: Autonomic dysfunction in patients with chronic intestinal pseudoobstruction. Clin Autonom Res 3:95–100, 1993

    Google Scholar 

  11. American Academy of Pediatrics and American Heart Association: Medications. In Textbook of Neonatal Resuscitation. RS Bloom, C Cropley, AHA/AAP Neonatal Resuscitation Program Steering Committee (eds). American Academy of Pediatrics, Evanston, Illinois, 1995, pp 6-3–6-51

    Google Scholar 

  12. Koch MB, Go VLW, DeMagno EP: Can plasma human pancreatic polypeptide be used to detect diseases of the exocrine pancreas? Mayo Clin Proc 60:259–265, 1985

    Google Scholar 

  13. Amarnath RP, Berseth CL, Malagelada J-R, Perrault J, Abell TL, Hoffman AD: Postnatal maturation of small intestinal motility in preterm and term infants. J Gastrointestin Motil 1:138–143, 1989

    Google Scholar 

  14. George JD: New clinical method for measuring the rate of gastric emptying: the double sampling test meal. Gut 9:237–242, 1968

    Google Scholar 

  15. Berseth CL: Neonatal small intestinal motility motor responses to feeding in term and preterm infants. J Pediatr 117:5:777–782, 1990

    Google Scholar 

  16. Houghton LA, Read NW, Heddle R, Maddern GJ, Downton J, Toouli J, Dent J: Motor activity of the gastric antrum, pylorus and duodenum under fasted conditions and after a liquid meal. Gastroenterol 94:1276–1284, 1988

    Google Scholar 

  17. Fox JE, Daniel EE, Jury J, Robotham H: Muscarinic inhibition of canine small intestinal motility in vivo. Am J Physiol 248:G526–G531, 1985

    Google Scholar 

  18. Ehlert FJ, Sawyer GW, Esqueda EE: Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle Life Sci 64:387–394, 1999

    Google Scholar 

  19. Lammering-Koppel M, Breiner-Schroder A, Drews U: Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H] quinuclidinyl benzlate autoradiography. Histochem Cell Biol 103:301–310, 1995

    Google Scholar 

  20. Tomomasa T, Hyman PE, Hsu CT, Jing J, Snape WJ Jr: Development of the muscarinic receptor in rabbit gastric smooth muscle. Am J Physiol 254:G680–G686, 1988

    Google Scholar 

  21. Zabielski R, Onaga T, Mineo H, Kato S: Periodic fluctuations in pancreatic secretion and duodenal motility investigated in neonatal calves. Exp Physiol 78:675–684, 1993

    Google Scholar 

  22. Large LT, Rauh JJ, DeMello FG, Klein WL: Two molecular weight forms of muscarininc acetylcholine receptors in the avian central nervous system: switch in differentiation of synapses. Proc Natl Acad Sci USA 82:8785–8789, 1985

    Google Scholar 

  23. McKinnon LA, Nathanson NM: Tissue specific regulation of muscarinic acetylcholine receptor expression during embryonic development. J Biol Chem 270:20636–20642, 1995

    Google Scholar 

  24. Tomomasa T, Yagi H, Kimura S, Snape WJ Jr, Hyman PE: Developmental changes in agonist-mediated gastric smooth muscle contraction in the rabbit. Pediatr Res 26:458–461, 1989

    Google Scholar 

  25. Hillemeier AC, Bitar KN, Biancani P: Developmental characteristics of the kitten antrum. Gastroenterology 101:339–343, 1991

    Google Scholar 

  26. Deutsch DE, Bitar KN, Hellemeier AC: Access to intracellular calcium during development in the feline gastric antrum. Pediatr Res 43:369–373, 1998

    Google Scholar 

  27. Sindel DB, Baker MD, Maisels MJ, Weinstein J: A comparison of papillary and cardiovascular effects of various mydriatic agents in preterm infants. J Pediatr Ophthalmol Strabis 23:273–276, 1986

    Google Scholar 

  28. Bonthala S, Musgrave V, Sparks J, Berseth CL: Mydriatics slow gastric emptying in preterm infants. J Pediatr 137:327–330, 2000

    Google Scholar 

  29. Isenberg SJ, Abrams C, Hyman PE: Effects of cyclopentolate eye drops on gastric secretory functions in preterm infants. Ophthamology 92:698–700, 1985

    Google Scholar 

  30. Lucas A, Adrian TE, Bloom SR, Aynsley-Green A: Plasma pancreatic polypeptide in the human neonate. Acta Paediatr Scand 69:211–221, 1980

    Google Scholar 

  31. Hyman PE, Clarke DD, Everett SL, Sonne B, Stewart D, Harada T, Walsh JH, Taylor IL: Gastric acid secretory function in preterm infants J Pediatr 106:467–468, 1980

    Google Scholar 

  32. Paje VU, Berseth CL: Comparison of intermittent bolus versus slow infusion feeding in preterm infants. Pediatr Res 49:261A, 2001

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

    Youhanna Al-Tawil & Carol Lynn Berseth

  2. Immunochemical Core Laboratory, Mayo Clinic and Foundation, Rochester, Minnesota, USA

    George Klee

Authors
  1. Youhanna Al-Tawil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. George Klee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carol Lynn Berseth
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Al-Tawil, Y., Klee, G. & Berseth, C.L. Extrinsic Neural Regulation of Antroduodenal Motor Activity in Preterm Infants. Dig Dis Sci 47, 2657–2663 (2002). https://doi.org/10.1023/A:1021084517391

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1021084517391

Search

Navigation