Abstract
Different mononuclear and dinuclear Cu complexes show high catalytic activity at concentrations 1-10 mM in the oxidation of ascorbic acid by peroxynitrite. Their activity is similar to the activity of Mn-porphyrin complexes and weakly depends on ligand environment, provided at least one free coordination site is available. The proposed reaction mechanism involves the intermediate formation of a copper-peroxynitrito complex, which reacts directly with ascorbic acid.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
M. Trujillo, M. Navillat, M.N. Alvarez, P. Peluffo, R. Radi: Analysis, 28, 518 (2000).
B. Halliwell, K. Zhao, M. Whiteman: Free Radical Research, 31, 651 (1999).
S. Pfeiffer, B. Mayer, B. Hemmens: Angew. Chem., Int. Ed., 38, 1715 (1999).
W.H. Koppenol: Met. Ions Biol. Syst., 36, 597 (1999).
J.T. Groves: Curr. Opin. Chem. Biol., 3, 226 (1999).
R. Radi, P. Peluffo, M.N. Alvarez, M. Naviliat, A. Cayota: Free Radical Biol. Med., 30, 463 (2001).
G.L. Squadrito, W.A. Pryor: Free Radical Biol. Med., 25, 392 (1998).
H. Sies, G.E. Arteel: Free Radical Biol. Med., 28, 1451 (2000).
W.A.M. Behrens, R. Madere: Anal. Biochem., 165, 102 (1987).
D. Bartlett, D.F. Church, P.L. Bounds, W.H. Koppenol: Free Radical Biol. Med., 18, 85 (1995).
G.L. Squadrito, X. Jin, W.A. Pryor: Arch. Biochem. Biophys., 322, 53 (1995).
J.T. Groves, S.S. Marla: J. Am. Chem. Soc., 117, 9578 (1995).
G.G.A. Balavoine, Y.V. Geletii, D. Bejan: Nitric Oxide, 1, 507 (1997).
Y.V. Geletii, A.J. Bailey, J.J. Cowan, I.A. Weinstock, C.L. Hill: Can. J. Chem., 79, 792 (2001).
M.K. Stern, M.P. Jensen, K. Kramer: J. Am. Chem. Soc., 118, 8735 (1996).
Yu.V. Geletii, A.J. Bailey, C.L. Hill: J. Chem. Soc., Dalton Trans., submitted (2002).
J. Lee, J.A. Hunt, J.T. Groves: J. Am. Chem. Soc., 120, 6053 (1998).
Yu.V. Geletii, A.J. Bailey, E. Boring, C.L. Hill: J. Chem. Soc., Chem. Comm., 1484 (2001).
W.H. Koppenol, R. Kissner, J.S. Beckman: Methods in Enzymology, 269, 296 (1996).
D.S. Bohle, B. Hansert, S.C. Paulson, B.D. Smith: J. Am. Chem. Soc., 116, 7423 (1994).
O.C.L. Casella, M. Gullotti, S. Garofani, P. Zanello: Inorg. Chem., 32, 2056 (1993).
L. Casella et al.: to be submitted.
J. Bas–Serra, I. Todorut, N. Casan–Pastor: Synth. React. Inorg. Met.–Org. Chem., 25, 869 (1995).
R.W. Hay, M.M. Hassan, Ch. You–Quan: J. Inorg. Biochem, 52, 17 (1993).
Alvarez, R. Radi: Free Radical Research, 34, 467 (2001).
J. Inczédy: Analytical Applications of Complex Equilibria, E. Horwood, Chichester 1976.
G. Battaini, L. Casella, M. Gullotti, E. Monzani, G. Nardin, A. Perotti, L. Randaccio, L. Santagostini, F.W. Heineman, S. Schindler: Eur. J. Inorg. Chem., submitted (2002).
C.F. Richard, D.L. Gustafson, A.E. Martel: J. Am. Chem. Soc., 81, (1959).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Geletii, Y.V., Patel, A.D., Hill, C.L. et al. Catalysis of ascorbic acid oxidation with peroxynitrite by biomimetic Cu -complexes. Reaction Kinetics and Catalysis Letters 77, 277–285 (2002). https://doi.org/10.1023/A:1020879717350
Issue Date:
DOI: https://doi.org/10.1023/A:1020879717350