Abstract
NCAM is known to play an important role in the regulation of neural development, functioning, and regeneration. To investigate the role of NCAM in a pathological state (experimental ischemia), we used a synthetic peptide, P2, mimicking physiological homophilic binding of NCAM. The viability, morphological and ultrastructural features, and metabolic activity of the cells in organotypic hippocampal cultures were estimated. Our data showed that pretreatment with P2 increased the cell viability and exerted a protective effect preventing changes of hippocampal cultures induced by ischemia. Thus, P2 can be supposed to be a promising agent for the further development of drugs for the treatment of neurodegenerative disorders.
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Skibo, G.G., Lushnikova, L., Voronin, K. et al. Effect of a Peptide Mimetic of NCAM on the Structure and Metabolic Activity of Organotypic Hippocampal Cultures during Induced Ischemia. Neurophysiology 34, 233–236 (2002). https://doi.org/10.1023/A:1020788308226
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DOI: https://doi.org/10.1023/A:1020788308226