Abstract
Impulse activities were recorded from neurons of the sensorimotor cortex of cats, trained to perform a conditioned placing reaction, before, during, and after iontophoretic application of the synaptically active drugs dopamine (DA) and GABA. Our experiments demonstrated that in most cases isolated application of DA increased the frequency of the impulse activity and the number of spikes related to the placing reaction. On the other hand, GABA evoked decreases in both indexes characterizing the impulse activity. In the case of co-application of DA with GABA, we observed both increases and decreases in the background firing rate activity and in the number of spikes related to the placing reaction. Our results suggest that interaction between the DA-ergic and GABA-ergic systems is realized at the receptor level and cannot be interpreted in an oversimplified manner.
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Rozumna, N.M. Interaction between the Dopaminergic and GABA-ergic Systems of the Cortex during Conditioning. Neurophysiology 34, 213–215 (2002). https://doi.org/10.1023/A:1020771804592
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DOI: https://doi.org/10.1023/A:1020771804592