Abstract
We studied the effects of application of bemitil, 2-ethylbenzimidazole hydrochloride, and 2-methyl benzimidazole hydrochloride in 10-5 and 10-4 M concentration on identified molluscan neurons. It was found that the agents exert clear neurotropic effect, which, as we assume, are determined by their influence on different types of ion channels.
Similar content being viewed by others
REFERENCES
M. A. Rozin, Proceedings of the Scientific Meeting on the Experimental Study and Clinical Testing of Dimezole [in Russian], Leningrad (1061), pp. 5–10.
M. A. Rozin, Synthesis of Protein and Cell Resistivity [in Russian], Nauka, Leningrad (1971), pp. 3–6.
N. V. Lazarev and M. A. Rozin, Sov. Med., No. 4, 24–26 (1951).
A. V. Smirnov, Pharmacological Remedies for Intensification of the Working Capacity [in Russian], Izd. Voenno-Med. Akad. im. A. V. Kirova, Leningrad (1984), pp. 31–35.
Yu. G. Bobkov, V. M. Vinogradov, and A. V. Smirnov, Proceedings of the 4th All-Union Conference on Purposeful Investigation of Physiologically Active Substances [in Russian], Riga (1981), p. 57.
V. M. Vinogradov and A. T. Grechko, Farmakol. Toksikol., 8, 5–9 (1982).
O. V. Kostyuchenko, V. I. Grishkovets, E. A. Sobolev, and I. I. Korenyuk, “Effects of triterpenic glycosides on modifications of the electrical activity of identified neurons,” Khim. Prir. Soedin., No. 1, 39–42 (2001).
T. V. Gamma, M. Yu. Ravaeva, D. R. Khusainov, and A. E. Kizilov, “Effects of biologically active compounds on the parameters of electrical activity of identified neurons of a mollusc, Helix albescens,” Uch. Zap. Tavrichesk. Nats. Univ., Ser. Biol., 14,No. 2, 21–26 (2001).
I. S. Magura and L. A. Vikhreva, “Voltage-gated K+ channels of the somatic membrane of molluscan neurons,” Neirofiziologiya, 16,No. 3, 296–307 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gamma, T.V., Korenyuk, I.I., Baevsky, M.Y. et al. Effects of Some Benzimidazole Derivatives on Electrical Activity in Molluscan Neurons. Neurophysiology 34, 130–132 (2002). https://doi.org/10.1023/A:1020753905984
Issue Date:
DOI: https://doi.org/10.1023/A:1020753905984