Abstract
Trimethylsilyl ethers of various hydroxyl-containing thiazole derivatives have been synthesized. The psychotropic activity (in vivo) and the cytotoxicity (in vitro on tumor cell lines HT-1080 and MG-22A) of these ethers and of their unsilylated precursors have been studied. It was discovered that the obtained compounds possess a sedative action. A moderate cytotoxic effect was detected for piperidine-containing thiazoles, displayed most strongly in relation to MG-22A cells.
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Zablotskaya, A., Segal, I., Germane, S. et al. Silyl Modification of Biologically Active Compounds. 8. Trimethylsilyl Ethers of Hydroxyl-containing Thiazole Derivatives. Chemistry of Heterocyclic Compounds 38, 859–866 (2002). https://doi.org/10.1023/A:1020698107686
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DOI: https://doi.org/10.1023/A:1020698107686