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Calcium Mechanism of Norepinephrine Activation of Ionic Pump in Somatic Cells of Lumbricus Terrestris Earthworm Muscle Wall

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Abstract

Blockade of norepinephrine-induced hyperpolarization in earthworm muscle cells was observed in a calcium-free medium, after substitution of Ca2+ with Mn2+, and in the presence of verapamil or chlorpromazine to the incubation saline. Changes in Ca2+ concentration in the saline and addition of caffeine had no effect on the resting potential of muscle cells. It was hypothesized that signal transduction from norepinephrine-activated membrane adrenoceptors to the ionic pump in earthworm muscle cells depends on influx of extracellular Ca2+ and subsequent involvement of Ca2+-accepting proteins similar to calmodulin in vertebrates.

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Authors and Affiliations

  1. Kazan' State Medical University, Russia

    E. M. Volkov, L. F. Nurullin, A. S. Obukhova, A. V. Chikin & E. E. Nikol'skii

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  1. E. M. Volkov
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  2. L. F. Nurullin
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  3. A. S. Obukhova
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  4. A. V. Chikin
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  5. E. E. Nikol'skii
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Volkov, E.M., Nurullin, L.F., Obukhova, A.S. et al. Calcium Mechanism of Norepinephrine Activation of Ionic Pump in Somatic Cells of Lumbricus Terrestris Earthworm Muscle Wall. Bulletin of Experimental Biology and Medicine 134, 18–19 (2002). https://doi.org/10.1023/A:1020688117507

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  • DOI: https://doi.org/10.1023/A:1020688117507

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