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Comparative study of Y3+ effect on calcium-dependent processes in frog cardiac muscle and mitochondria of rat cardiomyocytes

  • Comparative and Ontogenic Biochemistry
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Abstract

Inotropic effects of yttrium acetate (Y3+) on contractions of myocardium preparations of the frog Rana ridibunda, as well as on respiration and the inner membrane potential (ΔΨmito) of isolated rat heart mitochondria were studied. 2 mM yttrium in Ringer solution was found to significantly reduce the amplitude of myocardium contractions, evoked by electric stimulation, and increase the half-relaxation time (n = 5). In experiments with Ca2+, Y3+ decreased the Ca2+-dependent basal respiration rate in rat heart mitochondria, energized by glutamate and malate, impeded the reduction in respiration of these mitochondria operating in state 3 after Chance or uncoupled by 2,4-dinitrophenol, and inhibited a Ca2+-induced reduction in their inner membrane potential. The data obtained are important for better understanding the mechanism underlying Y3+ effects on the myocardial Ca2+-dependent processes. Possible mechanisms of the negative inotropic effect of Y3+ on myocardium and its influence on the Ca2+-dependent processes in rat mitochondria are discussed.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    S. M. Korotkov, K. V. Sobol’, I. V. Shemarova, V. V. Furaev & V. P. Nesterov

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  1. S. M. Korotkov
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  2. K. V. Sobol’
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  3. I. V. Shemarova
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  4. V. V. Furaev
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  5. V. P. Nesterov
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Correspondence to S. M. Korotkov.

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Original Russian Text © S.M. Korotkov, K.V. Sobol’, I.V. Shemarova, V.V. Furaev, V.P. Nesterov, 2016, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2016, Vol. 52, No. 3, pp. 177—183.

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Korotkov, S.M., Sobol’, K.V., Shemarova, I.V. et al. Comparative study of Y3+ effect on calcium-dependent processes in frog cardiac muscle and mitochondria of rat cardiomyocytes. J Evol Biochem Phys 52, 196–203 (2016). https://doi.org/10.1134/S0022093016030029

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  • DOI: https://doi.org/10.1134/S0022093016030029

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