Abstract
The effect of nibentan (2.5 and 25 muM) on extrasystolic and post-extrasystolic contraction of isolated and perfused papillary muscle was studied. The muscle contracted in an isometric regimen at a rate of external electrical stimulation of 0.5 Hz in a temperature-stabilized chamber (36.0±0.5°C). The extrasystolic contraction was induced with an extra electrical pulse applied 0.25 sec after the regular stimulus. Nibentan decreased the amplitude of extrasystolic contraction in a dose-dependent manner. At the same time, the effect of nibentan on extrasystolic contraction practically did not depend on its concentration. It is concluded that nibentan produces a dose-dependent effect on excitability of rat ventricular myocardium, and in parallel improves calcium-accumulating capacity of the sarcoplasmic reticulum in cardiomyocytes.
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Afanas'ev, S.A., Lukavskaya, I.A., Ugdyzhekova, D.S. et al. Effect of Class III Antiarrhythmic Preparation Nibentan on Extrasystolic and Post-Extrasystolic Contraction of Rat Papillary Muscle. Bulletin of Experimental Biology and Medicine 134, 15–17 (2002). https://doi.org/10.1023/A:1020636000669
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DOI: https://doi.org/10.1023/A:1020636000669