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The Role of Membrane Stage in the Interaction of Cortisol with Hepatocytes

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Abstract

We studied the effect of polyvinylpyrrolidone-immobilized cortisol on the distribution of glucocorticoid-receptor complexes in hepatocytes. Immobilized cortisol 1.2-1.5-fold increased the number of glucocorticoid-receptor complexes associated with the nuclei in a dose-dependent manner. The transport of glucocorticoid-receptor complexes into hepatocyte nuclei induced by immobilized cortisol is associated with their activation. Moreover, the ratio between nuclear pools of glucocorticoid-receptor complexes resistant to 0.2 and 0.4 M KCl extraction was changed. It was concluded that glucocorticoid binding to specific plasma membrane sites induced further stages of interaction between the hormone and competent cell.

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Authors and Affiliations

  1. Russian Medical State University, Moscow

    S. I. Ogurtsov & A. S. Dukhanin

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  1. S. I. Ogurtsov
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  2. A. S. Dukhanin
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Ogurtsov, S.I., Dukhanin, A.S. The Role of Membrane Stage in the Interaction of Cortisol with Hepatocytes. Bulletin of Experimental Biology and Medicine 133, 571–573 (2002). https://doi.org/10.1023/A:1020281708787

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  • DOI: https://doi.org/10.1023/A:1020281708787

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