Abstract
A sequential NMR based approach is proposed for measurements of high log K values at low ionic strength. [31P] NMR technique is used to determine the protonation constants of 1,2-diaminoethane-N,N,N′,N′-tetra(methylenephosphonic acid) (EDTPH, H8L) at 25°C in 0.1 mol-dm−3 KNO3 and at 37°C in 0.15 mol-dm−3 NaCl at pH 11–14. For equilibrium L + H ⇔ HL log K are found to be 13.3 (0.1) and 12.9 (0.1), respectively.
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References
T. Kiss, in Handbook of Metal-Ligand Interactions in Biological Fluids, G. Berthon, ed. (Marcel Dekker, New York, 1995), p. 717.
B. K. Keppler, ed., Metal Complexes in Cancer Chemotherapy (VCH, New York, 1993), pp. 85-129.
W. E. Gledhill and T. C. J. Feijtel, in The Handbook of Environmental Chemistry, Vol. 3, Part F, Detergents, O. Hutzinger, ed. (Springer Verlag, Berlin, 1992), pp. 261-285.
A. N. Serafini, Intern. J. Radiat. Oncol. Biol. Phys. 30, 1187(1994)
V. J. Lewington, Eur. J. Nucl. Med. 20, 66(1993).
K. Popov, H. Rönkkömäki, and L. H. J. Lajunen, Pure Appl. Chem., in press.
IUPAC Stability Constants Database (For Windows 95/98), Version 4.06. Copyright 1999; Com-piled by L. D. Pettit and H. K. Powell. Academic Software and K. J. Powell, Sourby Ald Farm, Timble; www.acadsoft.co.uk.
K. Popov, E. Niskanen, H. Rönkkömäki, and L. H. J. Lajunen, New J. Chem. 23, 1209(1999).
G. C. de Witt, P. M. May, J. Webb, and G. Hefter, Inorg. Chim. Acta 275-276, 37(1998).
N. V. Jarvis, J. M. Wagener, and G. E. Jackson, J. Chem. Soc Dalton. Trans., p. 1411(1995).
K. Sawada, T. Miyagawa, T. Sakaguchi, and K. Doi, J. Chem. Soc. Dalton Trans., p. 3777(1993).
K. Sawada, M. Kuribayashi, T. Suzuki, and H. Miyamoto, J. Solution Chem. 20, 829(1991).
I. N. Marov, L. V. Ruzaikina, V. A. Ryabukhin, P. A. Korovaikov, and N. M. Dyatlova, Koord. Khim. 3, 1233(1977) (Engl. 1038).
R. Motekaitis, I. Murase, and A. E. Martell, Inorg. Chem. 15, 2303(1977).
R. Motekaitis, I. Murase, and A. E. Martell, Inorg. Nucl. Chem. Lett. 7, 1103(1971).
S. Westerback, K. Rajan, and A. E. Martell, J. Amer. Chem. Soc. 87, 2567(1965).
S. Westerback and A. E. Martell, Nature (London) 178, 321(1956).
E. Rizkalla and M. Zaki, Talanta 26, 507(1979).
J. M. Wagener and N. V. Jarvis, S. Afr. J. Chem. 28, 85(1995).
E. Uhlig and W. Achilles, Z. Chem. 3, 109(1965).
M. I. Kabachnik, N. M. Dyatlova, R. P. Lastovskii, T. Ya. Medved', Yu. F. Belugin, and V. V. Sidorenko, Dokl. Akad. Nauk SSSR 175, 621(1967) (Engl. 351).
M. T. Beck and I. Nagypal. Chemistry of Complex Equilibria (Ellis Horwood, Chichester, 1989).
I. Kron, S. L. Marshall, P. M. May, G. Hefter, and E. Könögsberger, Monats. Chem. 126, 315(1995).
J. Duffield, P. M. May, and D. R. Williams, J. Inorg. Biochem. 20, 199(1984).
SigmaPlot for Windows, Version 4.0, 1986–1997 SPSS Inc.
E. N. Rizkalla and G. R. Choppin, Inorg. Chem. 22, 1478(1983).
L. T. Tikhonova, Radiokhimiya 2, 519(1970).
T. Ichikawa and K. Sawada, Bull. Chem. Soc. Jpn. 70, 829(1997).
A. Ringbom, Complexation in Analytical Chemistry (Weley-Interscience, New York, 1963), p. 36.
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Popov, K., Popov, A., Rönkkömäki, H. et al. An NMR-Based Approach to the Measurement of High Log K HL Values at Low Ionic Strength. 31P NMR Study of 1,2-Diaminoethane-N,N,N′,N′-tetra(methylenephosphonic Acid) Protonation Equilibrium at pH > 12. Journal of Solution Chemistry 31, 511–520 (2002). https://doi.org/10.1023/A:1020273730498
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DOI: https://doi.org/10.1023/A:1020273730498