Skip to main content
SpringerLink
Log in

Tumor Necrosis Factor-Induced Cytotoxicity is Not Related to Rates of Mitochondrial Morphological Abnormalities or Autophagy-Changes that can be Mediated by TNFR-I or TNFR-II

  • Published:
Bioscience Reports

Abstract

Tumor necrosis factor (TNF) may cause apoptosis or necrosis and induces mitochondrial changes that have been proposed to be central to cytotoxicity. We report similar patterns of TNF-induced mitochondrial morphological alterations and autophagy in cell types with differing sensitivity to TNF-induced cytotoxicity. Specific ligation of TNFR-I or TNFR-II induces different rates of apoptosis and mitochondrial morphological change, but similar rates of autophagy. These changes do not invariably lead to cell death, and survival or progression to apoptosis or necrosis following TNF exposure may depend in part on the extent of mitochondrial damage and/or the autophagic capacity of the cell.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  • Arstila, A. U. and Trump, B. F. (1968) Am. J. Path. 53:687–733.

    Google Scholar 

  • Bazzoni, F. and Beutler, B. (1996) N. Engl. J. Med. 334:1717–1725.

    Google Scholar 

  • Blommaart, E. F. C., Luiken, J. J. F. P., and Meijer, A. J. (1997) Histochem. J. 29:365–385.

    Google Scholar 

  • Bright, N. A., Reaves, B. J., Mullock, B. M., and Luzio, J. P. (1997) J. Cell. Sci. 110:2027–2040.

    Google Scholar 

  • Cossarizza, A. et al. (1996) Exp. Cell. Res. 220:232–240.

    Google Scholar 

  • Culic, O., Gruwel, M. L. H., and Schrader, J. (1997) Am. J. Physiol. 273:C205–C213.

    Google Scholar 

  • De Vos, K. et al. (1998) J. Biol. Chem. 273:9673–9680.

    Google Scholar 

  • Fiers, W. (1991) FEBS Lett. 285:199–212.

    Google Scholar 

  • Fischer, C. P., Bode, B. P., and Souba, W. W. (1998) Ann. Surg. 227:627–634.

    Google Scholar 

  • Goossens, V., Grooten, J., De Vos, K., and Fiers, W. (1995) Proc. Natl. Acad. Sci. U.S.A. 92:8115–8119.

    Google Scholar 

  • Green, D. and Kroemer, G. (1998) Trends Cell Biol. 8:267–271.

    Google Scholar 

  • Hampton, M. B., Zhivotovsky, B., Slater, A. F. G., Burgess, D. H., and Orrenius, S. (1998) Biochem. J. 329:95–99.

    Google Scholar 

  • Hennet, T., Richter, C., and Peterhans, E. (1993) Biochem. J. 289:587–592.

    Google Scholar 

  • Jia, L. et al. (1997) Br. J. Haematol. 98:673–685.

    Google Scholar 

  • Kerr, J. F. R., Wyllie, A. H., and Currie, A. R. (1972) Br. J. Cancer 26:239–257.

    Google Scholar 

  • Lancaster, J. R. J., Laster, S. M., and Gooding, L. R. (1989) FEBS Lett. 248:169–174.

    Google Scholar 

  • Leist, M., Single, B., Castoldi, A. F., Kühnle, S., and Nicotera, P. (1997) J. Exp. Med. 185:1481–1486.

    Google Scholar 

  • Levrat, C. and Lousot, P. (1996) Biochem. Biophys. Res. Commun. 221:531–538.

    Google Scholar 

  • Marzella, L. and Glaumann, H. (1987) in: Lysosomes: Their Role in Protein Breakdown. Glaumann, H. and Ballard, F. J., eds., New York: Academic Press, pp. 319–367.

    Google Scholar 

  • Matthews, N. (1983) Br. J. Cancer 48:405–410.

    Google Scholar 

  • Mosselmans, R., Hepburn, A., Dumont, J. E., Fiers, W., and Galand, P. (1988). J. Immunol. 141:3096–3100.

    Google Scholar 

  • Pastorino, J. G., Simbula, G., Yamamoto, K., Glascott, P. A., J., Rothman, R. J., and Farber, J. L. (1996) J. Biol. Chem. 271:29792–29798.

    Google Scholar 

  • Polla, B. S. et al. (1996) Free Rad. Res. 25:125–131.

    Google Scholar 

  • Prins, J. B. et al. (1997) Diabetes 46:1939–1944.

    Google Scholar 

  • Reed, J. C. (1997) Cell 91:559–562.

    Google Scholar 

  • Reipert, S., Hickman, J. A., and Allen, T. D. (1996) J. Histochem. Cytochem. 44:549–558.

    Google Scholar 

  • Richter, C. (1993) FEBS Lett. 325:104–107.

    Google Scholar 

  • Richter, C., Schweizer, M., Cossarizza, A., and Franceschi, C. (1996) FEBS Lett. 378:107–110.

    Google Scholar 

  • Schulze-Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A., and Fiers, W. (1992) J. Biol. Chem. 267:5317–5323.

    Google Scholar 

  • Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., and Fiers, W. (1993) EMBO J. 12:3095–3104.

    Google Scholar 

  • Seglen, P. O. and Bohley, P. (1992) Experientia 48:158–172.

    Google Scholar 

  • Skulachev, V. P. (1998) FEBS Lett. 423:275–280.

    Google Scholar 

  • Slowik, M. R., Min, W., Ardito, T., Karsan, A., Kashgarian, M., and Pober, J. S. (1997) Lab. Invest. 77:257–267.

    Google Scholar 

  • Tang, D. G., Li, L., Zhu, Z., and Joshi, B. (1998) Biochem. Biophys. Res. Commun. 242:380–384.

    Google Scholar 

  • Vandenabeele, P., Declercq, W., Beyaert, R., and Fiers, W. (1995) Trends Cell Biol. 5:392–399.

    Google Scholar 

  • Walker, N. I., Winterford, C. M., Williamson, R. M., and Kerr, J. F. R. (1993) Pancreas 8:443–449.

    Google Scholar 

  • Zakeri, Z., Bursch, W., Tenniswood, M., and Lockshin, R. A. (1995) Cell Death Differ. 2:87–96.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR, U.K

    Johannes B. Prins, Elizabeth C. Ledgerwood, Paulo R. Faraco, Nicholas A. Bright, Stephen O'Rahilly & John R. Bradley

  2. Department of Molecular Biology, Flanders' Interuniversity Institute for Biotechnology, University of Gent, Gent, Belgium

    Paul Ameloot & Peter Vandenabeele

Authors
  1. Johannes B. Prins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Elizabeth C. Ledgerwood
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paul Ameloot
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peter Vandenabeele
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Paulo R. Faraco
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nicholas A. Bright
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Stephen O'Rahilly
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. John R. Bradley
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

These authors contributed equally to the manuscript

Rights and permissions

Reprints and permissions

About this article

Cite this article

Prins, J.B., Ledgerwood, E.C., Ameloot, P. et al. Tumor Necrosis Factor-Induced Cytotoxicity is Not Related to Rates of Mitochondrial Morphological Abnormalities or Autophagy-Changes that can be Mediated by TNFR-I or TNFR-II. Biosci Rep 18, 329–340 (1998). https://doi.org/10.1023/A:1020261316486

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020261316486

Search

Navigation