Skip to main content
SpringerLink
Log in

Tripeptide Gly-His-Lys is a Hepatotropic Immunosuppressor

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. I. G. Akmaev and V. V. Grinevich, Byull. Eksp. Biol. Med., 131,No. 1, 22–32 (2001).

    Google Scholar 

  2. I. N. Alekseeva, T. M. Bryzgina, S. I. Pavlovich, and N. V. Il'chevich, Liver and Immune Reactivity [in Russian], Kiev (1991).

  3. Immunological Methods [in Russian], Ed. G. Frimel', Moscow (1987).

  4. B. I. Kuznik, V. G. Morozov, and V. Kh. Khavinson, Cytomedines. Experience of 25–Year Experimental and Clinical Studies [in Russian], St. Petersburg (1998).

  5. A. D. Chernousov, L. N. Fontalin, and T. K. Kondrat'ev, Byull. Eksp. Biol. Med., 87,No. 5, 449–452 (1979).

    Google Scholar 

  6. M. C. Linder, Biochemistry of Copper, Ed. E. Freiden, New York (1991).

  7. F. X. Maquart, G. Bellon, B. Chaqour, et al., J. Clin. Invest., 95,No. 5, 2368–2376 (1993).

    Google Scholar 

  8. F. X. Maquart, L. Pickart, M. Laurent, et al., FEBS Lett., 238,No. 2, 343–346 (1988).

    Google Scholar 

  9. L. Pickart and S. Lovejoy, Methods Enzymol., 147, 314–328 (1987).

    Google Scholar 

  10. R. E. Trackhy, T. D. Fors, L. Pickart, et al., Ann. N. Y. Acad. Sci., 642, 468–469 (1991).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathophysiology, Kursk State Medical University, Russia

    M. Yu. Smakhtin, L. A. Sever'yanova, A. I. Konoplya & I. A. Shveinov

Authors
  1. M. Yu. Smakhtin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. A. Sever'yanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. I. Konoplya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. A. Shveinov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Yu. Smakhtin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smakhtin, M.Y., Sever'yanova, L.A., Konoplya, A.I. et al. Tripeptide Gly-His-Lys is a Hepatotropic Immunosuppressor. Bulletin of Experimental Biology and Medicine 133, 586–587 (2002). https://doi.org/10.1023/A:1020242127443

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020242127443

Search

Navigation