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Intestinal Transit of Fat Depends on Accelerating Effect of Cholecystokinin and Slowing Effect of an Opioid Pathway

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Abstract

Fat has been described to both accelerate and slow intestinal transit. We hypothesized that the fat-induced jejunal brake depends on the combined accelerating effect of CCK and the slowing effect of an opioid pathway. Using a multifistulated model, intestinal transit was measured in four dogs, while 60 mM oleate was delivered into the proximal gut with either 0 or 6 mg naloxone, and 0.1 mg/kg devazepide (a peripheral CCK-A-receptor antagonist) administered intraluminally and intravenously, respectively. In a second study, intestinal transit was measured in seven dogs, while naloxone was delivered intraluminally at 0-, 3-, 6-, or 12-mg doses. Compared to the jejunal brake (marker recovery of 50.1 ± 2.6%), intestinal transit was slowed by the CCK-A antagonist (36.4 ± 8.3%; P < 0.05) and accelerated by naloxone (82.0 ± 6.8%; P < 0.05). The accelerating effect of CCK occurred early in the transit response, while the dose-dependent effect (P < 0.05) of naloxone occurred later. We conclude that fat-induced jejunal brake depends on the early accelerating effect of CCK and the later slowing effect of a naloxone-sensitive opioid pathway.

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Authors and Affiliations

  1. GI Motility Program and Section of Nutrition, Department of Medicine, Cedars-Sinai Medical Center, CSMC Burns & Allen Research Institute, Los Angeles, California, 90048, USA

    Henry C. Lin, Oren Zaidel & Susan Hum

  2. School of Medicine, University of California, Los Angeles, Los Angeles, California, 90024, USA

    Henry C. Lin

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  1. Henry C. Lin
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  2. Oren Zaidel
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Lin, H.C., Zaidel, O. & Hum, S. Intestinal Transit of Fat Depends on Accelerating Effect of Cholecystokinin and Slowing Effect of an Opioid Pathway. Dig Dis Sci 47, 2217–2221 (2002). https://doi.org/10.1023/A:1020179009559

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