Skip to main content
Log in

Bone bank service in Odense, Denmark. Audit of the first ten years with bone banking at the Department of Orthopaedics, Odense University Hospital

  • Published:
Cell and Tissue Banking Aims and scope Submit manuscript

Abstract

There has been an increase in the demand for allograft bone in recentyears. The Odense University Hospital bone bank has been in function since1990,and this paper outlines our results during the 10 year period 1990–1999.Potential donors were screened by contemporary banking techniques which includea social history, donor serum tests for HIV, hepatitis B and C, and graftmicrobiology. The bones were stored at −80 °C. No typeofsecondary sterilisation was made. 423 femoral heads were approved and donatedto300 patients,1–6 heads/operation. The allografts have been used mainly toreconstruct defects at revision hip arthroplasty (34%), and for fracturesurgery(24%). 7 % of all transplanted patients were reoperated because of infection.Inthe hip revision group the infection rate was 4 %. There were no cases ofdisease transmission. During the 10 year period there was a change in theclinical use of the allografts. In the first years the allografts were mainlyused for spinal fusion surgery, but today the majority are used in hip revisionand fracture surgery. The clinical results correspond to those reported inlarger international series.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Aho A.J.,Ekfors T.,Dean P.B.,Aro H.T.,Ahonen A. andNikkanen V. 1994. Incorporation and clinical results of large allografts of the extremities and pelvis. Clin. Orthop. 307: 200–213.

    Google Scholar 

  • Aho A.J.,Hirn M.,Aro H.T.,Heikkilae J.T. andMeurman O. 1998. Bone bank service in Finland. Experience of bacteriologic, serologic and clinical results of the Turku Bone Bank 1972–1995. Acta Orthop Scand 69: 559–565.

    Google Scholar 

  • Allan D.G.,Lavoie B.J.,Mcdonald S.,Oakesshott R. andGross A.E. 1991. Proximal femoral allografts in revision hip arthroplasty. J. Bone Joint Surg.(Br) 73: 235–240.

    Google Scholar 

  • American Association of Tissue Banks 1992. Technical manual for tissue banking. AATB.

  • Andersen M.B.,Larsen S.,Feld R. andOvesen O. 2000. Bone Banking-answers from a danish questionnaire. Proceedings Dissertations, Acta Orthopaedica Scandinavica.

  • Center of Disease control 1988. Transmission of HIV through bone transplantation: case report and public health recommendations. MMWR 37: 597.

    Google Scholar 

  • Deijkers R.L.M.,Bloem R.M.,Petit P.L.C.,Brand R.,Vehmeyer S.B.W. andVeen M.R. 1997. Contamination of bone allografts. Analysis of incidence and predisposing factors. J Bone Joint Surg(Br) 79: 161–166.

    Google Scholar 

  • Dickmeiss E.,Christiansen A.H. andSmith E. 2001. Screening of donor blood for viral markers. Anti-HIV, HbsAg and anti-HTLV-I/II in Denmark 1990–1999. Dan. Med. Bull. 163: 2623–2628.

    Google Scholar 

  • European Association of Musculo-skeletal Transplan-tation(EAMST),European Association of Tissue Banks(EATB), Vienna 1997. The Commom Standards for Musculoskeletal Tissue Banking.

  • Hansen C.Ä.,Mejdahl S. andReimann I. 1994. Bone banking in Denmark, results of a nationwide survey. Dan. Med. Bull. 41: 574–576.

    Google Scholar 

  • Hernigou P.,Delepine G., Goutailler and Julieron A. 1993. Massive allografts sterilised by irradiation. Clinical results. J Bone Joint Surg (Br) 75: 904–13.

  • Hernigou P.,Gras G.,Marinello G. andDormont D. 2000. Inactivation of HIV by application of heat and radiation. Implication in bone banking with irradiated allograft bone. Acta Orthop Scand 71: 508–512.

    Google Scholar 

  • Husted H. andKramhøft M.U. 1996. Microbiologi in bone banking. Dan Med Bull 44: 6260–6262.

    Google Scholar 

  • Ivory J.P. andThomas I.H. 1993. Audit of a bone bank. J. Bone. Surg.(Br) 75: 355–357.

    Google Scholar 

  • Khan M.T.,Stockley I. andIbbotson C. 1998. Allograft bone transplantation: a Sheffield experience. Ann. R. Coll. Surg. Engl. 80: 150–153.

    Google Scholar 

  • Korkala O.,Jokinen M. andMatikainen A. 1994. Three years audit of a bone bank. Ann. Chir. Gynaecol. 83: 244–250.

    Google Scholar 

  • Lawrence J.M.,Engh C.A. andMacalino G.E. 1993. Revision total hip arthroplasty: long term results without cement. Orthop. Clin North. Am. 24: 635–644.

    Google Scholar 

  • Loty B.,Tomeno B.,Evrard J. andPostel M. 1994. Infection in bone allografts sterilized by radiation. Int. Orthop.(SICOT) 18: 164–171.

    Google Scholar 

  • Sanzen L. andCarlsson A. 1997. Transmission of human T-cell lymphotropic virus type 1 by a deep-frozen bone allograft. Acta. Orthop. Scand. 68: 72–74.

    Google Scholar 

  • Simonds R.J.,Holmberg S.D. andHurwitz R.L. et al. 1992. Transmission of human immunodefiency virus type 1 from a seronegative organ and tissue donor. N. Engl. J. Med. 326: 726–732.

    Google Scholar 

  • Sundhedsstyrelsen, København (Danish National Board of Health) 1991. Vejledning om forebyggelse mod hepatitis. Maj, (In danish).

  • Sundhedsstyrelsen, København (Danish National Board of Health) 1994. Retningslinier af. 27. Januar J. nr. 4430–2–1993.

  • Tomford W.W. 1995. Transmission of disease through transplantation of musculoskeletal allografts. J Bone Joint Surg(Am) 77: 1742–1754.

    Google Scholar 

  • Tomford W.W. andMankin H.J. 1999. Bone banking. Update on methods and materials. Orthop Clin North Am 30: 565–570.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nielsen, H.T., Larsen, S., Andersen, M. et al. Bone bank service in Odense, Denmark. Audit of the first ten years with bone banking at the Department of Orthopaedics, Odense University Hospital. Cell Tissue Banking 2, 179–183 (2001). https://doi.org/10.1023/A:1020162323539

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020162323539

Navigation