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Mathematical Analysis of Subtypes of Muscarinic Receptors Modulating Heart and Respiratory Rhythms in Rats

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Abstract

Mathematical analysis of the data obtained in experiments on the whole organism revealed that blockade of M2-cholinergic receptors increased both heart and respiratory rates. Blockade of M1-cholinergic receptors alleviated tachycardia induced by M2-receptor blockade.

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Authors and Affiliations

  1. Institute of Toxicology, Ministry of Health of the Russian Federation, St. Petersburg, Russia

    A. V. Lychakov, V. A. Belyaev, A. B. Kosmachev, R. I. Glukhova, S. G. Dagaev & V. B. Dolgo-Saburov

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  1. A. V. Lychakov
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  2. V. A. Belyaev
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  3. A. B. Kosmachev
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  4. R. I. Glukhova
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  5. S. G. Dagaev
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  6. V. B. Dolgo-Saburov
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Lychakov, A.V., Belyaev, V.A., Kosmachev, A.B. et al. Mathematical Analysis of Subtypes of Muscarinic Receptors Modulating Heart and Respiratory Rhythms in Rats. Bulletin of Experimental Biology and Medicine 133, 515–517 (2002). https://doi.org/10.1023/A:1019890527480

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  • DOI: https://doi.org/10.1023/A:1019890527480

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