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Review Article: Clinical Nutrition in Pancreatitis

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Abstract

In patients with acute pancreatitis or an acuteflare of chronic pancreatitis, a discrepancy existsbetween increased protein/calorie requirements inducedby a hypermetabolic stress state and reducedingestion/assimilation of exogenous nutrients, which promotesprogressive nutritional deterioration. Patients withsevere pancreatitis (defined by ≥3 Ranson criteria,an APACHE II score of ≥10, development of major organfailure, and/or presence of pancreatic necrosis) aremore likely to require aggressive nutritional supportthan patients with mild disease. The type of formula andlevel of the gastrointestinal tract into which nutrients are infused determine the degree towhich pancreatic exocrine secretion is stimulated.Animal studies and early prospective randomizedcontrolled trials in humans suggest that total enteralnutrition via jejunal feeding may be the preferred routeto parenteral alimentation in this diseasesetting.

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Authors
  1. Stephen A. Mcclave
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  2. Harvy Snider
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  3. Nancy Owens
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  4. Leslie K. Sexton
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Mcclave, S.A., Snider, H., Owens, N. et al. Review Article: Clinical Nutrition in Pancreatitis. Dig Dis Sci 42, 2035–2044 (1997). https://doi.org/10.1023/A:1018806131924

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