Abstract
A composite of polyhydroxybutyrate (PHB) polymer, reinforced with synthetic hydroxyapatite (HA) particles, with potential as a bone-analogue material, was examined microscopically using scanning electron microscopy and transmission electron microscopy. These imaging techniques provide the means of understanding and monitoring the morphological and structural behaviour of retrieved implants. Scanning electron microscopy was used to assess the overall mechanism of new bone formation at the implant interface after up to 6 months implantation. This procedure was followed by a detailed ultrastructural examination at lattice plane resolution level, using high resolution electron microscopy and selected area diffraction of the regions showing bone apposition. Fine hydroxyapatite crystallites were found to form at the interface after in vivo implantation into cortical bone.
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C. DOYLE, D. SAUNDERS and W. BONFIELD, in Plastic and Rubber Institute Conference, Composites in Biomedical Engineering, London, 1985.
C. DOYLE, Z. B. LUKLINSKA, K. E. TANNER and W. BONFIELD, in ‘‘Clinical implant materials’’, edited by G. Heimke, U. Soltesz, A. J. C. Lee, ‘‘Advances in Biomaterials, Vol. 9’’ (Elsevier Science Publishers, Amsterdam, 1990) pp. 339–344.
J. C. KNOWLES and G. W. HASTINGS, J. Mater. Sci., Mater. Med. 3 1992) 352–358
J. C. KNOWLES, Med. Engng Technol. 17 (1993) 129–137.
C. DOYLE, K. E. TANNER and W. BONFIELD, Biomaterials 12 (1991) 841–847.
W. BONFIELD and Z. B. LUKLINSKA, in ‘‘The bonebiomaterials interface’’, edited by J. E. Davies (University of Toronto Press, 1991) pp. 89–93.
R. N. DOWNES, S. VARDY, K. E. TANNER and W. BONFIELD, in ‘‘Bioceramics,’’ edited by W. Bonfield, G. W. Hastings and K. E. Tanner, Proceedings of the 4th International Symposium on Ceramics in Medicine, London, September 1991, Vol. 4, pp. 239–246.
M. NEO, T. NAKAMURA, T. YAMAMURO, C. OHTSUKI and T. KOKUBO, in ‘‘Bone-bonding biomaterials’’, edited by P. Ducheyne, T. Kokubo and C. A. van Blitterswijk, (Reed Healthcare Communications, 1992) pp. 112–120.
R. Z. LEGEROS, G. DACULSI, I. ORLY, M. GREGOIRE, M. HEUGHEBAERT, M. GINESTE and R. KIJKOWASKA, in ‘‘Bone-bonding biomaterials’’, edited by P. Ducheyne, T. Kokubo and C. A. van Blitterswijk, (Reed Healthcare Communications, 1992) pp. 201–212.
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LUKLINSKA , Z.B., BONFIELD , W. Morphology and ultrastructure of the interface between hydroxyapatite-polyhydroxybutyrate composite implant and bone. Journal of Materials Science: Materials in Medicine 8, 379–383 (1997). https://doi.org/10.1023/A:1018589018205
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DOI: https://doi.org/10.1023/A:1018589018205