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Lipase-catalyzed esterification in organic solvent to resolve racemic naproxen

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Abstract

Lipase from Candida cylindracea was used to catalyze the enantioselective esterification in isooctane to resolve naproxen. The conversion was 33.5% over 11 days. The enantiomer excess of product (ee %) was about 100% at this conversion when octanol acted as the other substrate.

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Authors and Affiliations

  1. Research Institute of Biochemistry, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China

    Y.-m. Cui, D.-z. Wei & J.-t. Yu

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  1. Y.-m. Cui
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  2. D.-z. Wei
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  3. J.-t. Yu
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Cui, Ym., Wei, Dz. & Yu, Jt. Lipase-catalyzed esterification in organic solvent to resolve racemic naproxen. Biotechnology Letters 19, 865–868 (1997). https://doi.org/10.1023/A:1018333503317

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  • DOI: https://doi.org/10.1023/A:1018333503317

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