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Prostaglandin E2 Release by Human and Syrian Hamster Tumor Cells and Their Sensitivity to Cytostatic Activity of Natural Killers

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Abstract

The release of prostaglandin E2 by human and Syrian hamster tumor cells in response to contact with natural killers and their sensitivity to cytostatic activity of natural killers were studied. A previously reported correlation between prostaglandin E2 release by Syrian hamster tumor cells and their resistance to cytostatic activity of natural killers was confirmed. This resistance can be cancelled by inhibition of prostaglandin E2 release with indomethacin. Unlike malignant tumor cells of Syrian hamsters, only few human tumor cells resistant to cytostatic activity of natural killers secrete prostaglandin E2. The resistance of these cell strains to cytostatic activity of natural killers could be cancelled by indomethacin treatment. Possible role of prostaglandin E2 release as a mechanism of tumor cell protection from effector cells of this type of natural (congenital) immunity is discussed.

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Authors and Affiliations

  1. Laboratory of Antitumor Immunity, Institute of Carcinogenesis, All-Russian N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    V. A. Matveeva

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  1. V. A. Matveeva
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Matveeva, V.A. Prostaglandin E2 Release by Human and Syrian Hamster Tumor Cells and Their Sensitivity to Cytostatic Activity of Natural Killers. Bulletin of Experimental Biology and Medicine 131, 156–158 (2001). https://doi.org/10.1023/A:1017596029350

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  • DOI: https://doi.org/10.1023/A:1017596029350

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