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Effects of New Taurine Derivatives on Primary Immune Response in Rats

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Abstract

The effects of new taurine derivatives TAU-15 and TAU-60 with normal and branched alkyl chains, respectively, in a dose of 25 mg/kg on the primary immune response in rats were studied in rats. Intraperitoneal injections of test compounds for 24 days caused transient inhibition of immune reactions to thymus-dependent antigen, which was related to suppressed production of interleukin-1β playing a key role in antigen presentation. This effect was probably associated with activation of cortisol secretion. TAU-15 inhibited production of tumor necrosis factor-α and, therefore, prevented tissue damages. The immune response was normalized after withdrawal of these preparations.

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Authors and Affiliations

  1. Russian Academy of Medical Sciences, St. Petersburg

    N. S. Sapronov, L. K. Khnychenko & A. V. Polevshchikov

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  1. N. S. Sapronov
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  2. L. K. Khnychenko
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  3. A. V. Polevshchikov
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Sapronov, N.S., Khnychenko, L.K. & Polevshchikov, A.V. Effects of New Taurine Derivatives on Primary Immune Response in Rats. Bulletin of Experimental Biology and Medicine 131, 142–144 (2001). https://doi.org/10.1023/A:1017587727533

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  • DOI: https://doi.org/10.1023/A:1017587727533

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