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Molecular, Genetic, and Morphological Markers during Persistence of RNA-Containing Hepatitis C Virus in the Body

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Abstract

A comparison of 5'-UTR structures in Siberian isolates of hepatitis C virus showed that the majority of genotyped samples had 1b genotype. A correlation was found between HLA antigens and their stable complexes and clinical manifestations of hepatitis C. We revealed immunogenetic criteria of organism's resistance or susceptibility to hepatitis C virus. The presence of hepatitis C virus RNA in the serum determined by the reverse transcription polymerase chain reaction was accompanied by the appearance of pathomorphological signs characteristic of liver tissue infection, but did not correspond to the severity of fibrosis.

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Authors and Affiliations

  1. Department of Infectious Diseases, Novosibirsk State Medical Academy, Novosibirsk

    N. P. Tolokonskaya, G. I. Nepomnyashchikh, V. I. Konenkov & S. V. Netesov

  2. Laboratory of Ultrastructural Basics of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Russia

    N. P. Tolokonskaya, G. I. Nepomnyashchikh, V. I. Konenkov & S. V. Netesov

  3. Laboratory of Clinical Immunogenetics, Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Russia

    N. P. Tolokonskaya, G. I. Nepomnyashchikh, V. I. Konenkov & S. V. Netesov

  4. Laboratory of Molecular Biology of RNA-Containing Viruses, State Research Center Vektor, Novosibirsk

    N. P. Tolokonskaya, G. I. Nepomnyashchikh, V. I. Konenkov & S. V. Netesov

Authors
  1. N. P. Tolokonskaya
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  2. G. I. Nepomnyashchikh
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  3. V. I. Konenkov
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  4. S. V. Netesov
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Tolokonskaya, N.P., Nepomnyashchikh, G.I., Konenkov, V.I. et al. Molecular, Genetic, and Morphological Markers during Persistence of RNA-Containing Hepatitis C Virus in the Body. Bulletin of Experimental Biology and Medicine 131, 145–149 (2001). https://doi.org/10.1023/A:1017539811604

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  • DOI: https://doi.org/10.1023/A:1017539811604

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