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Role of Apoptosis in Age-Related Pathologies

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Abstract

A review of recent data concerning the apoptotic death of cells during senescence at the organismic level. The data analyzed suggest interrelations between apoptosis deregulation and some age-related pathologies and senescent phenotypes. Genetic aspects and possible mechanisms of age-related changes in the program of apoptosis are considered. It has been proposed that age-related deregulation of apoptosis is a mechanism of senescence.

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  1. Institute of Biology, Komi Research Center, Ural Division, Russian Academy of Sciences, Syktyvkar, 167000, Komi Republic, Russia

    V. G. Zainullin

  2. Syktyvkar State University, Syktyvkar, 167982, Russia

    A. A. Moskalev

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  1. V. G. Zainullin
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Zainullin, V.G., Moskalev, A.A. Role of Apoptosis in Age-Related Pathologies. Russian Journal of Developmental Biology 32, 199–204 (2001). https://doi.org/10.1023/A:1016766516285

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