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The Interaction of the rad201Gene with Genes mei-9and mei-41in Germline Cells of DrosophilaFemales

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Abstract

The effect of Drosophilamutation rad201 G1together with mutations mei-41 D5and mei-9 aon the sensitivity of oocytes to induction of dominant lethals (DLs) was studied. To this end, the frequencies of spontaneous and gamma-radiation-induced DLs in consecutive egg batches of females carrying double or single mutations were estimated. Since the effects of the mutations examined are expressed only at the previtellogenetic stages of oogenesis, only newly hatched (0–5-hour-old) females, whose oocytes did not develop farther than stage 7, were irradiated. The results obtained indicated that in intact and irradiated oocytes of double mutants mei-9 a rad201 G1and mei-41 D5 rad201 G1, mutation rad201 G1epistatically suppresses the mutations of the both meigenes.

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REFERENCES

  1. Snow, R., Mutants of Yeast Sensitive to Ultraviolet Light, J. Bacteriol., 1967, vol. 94, pp. 571-575.

    Google Scholar 

  2. Varentsova, E.R. and Khromykh, Yu.M., Interaction of Mutations of the mei-9, mei-41, and rad201 Genes for Mutagen Sensitivity in Drosophila Exposed to Ionizing Radiation, Genetika (Moscow), 1997, vol. 33, no. 3, pp. 328-332.

    Google Scholar 

  3. Khromykh, Yu.M. and Kotlovanova, L.V., The rad201 Gene Controls Cell-Cycle Arrest in Irradiated Drosophila Cells, Genetika (Moscow), vol. 37, no. 0, p. 0.

  4. Sarantseva, S.V. and Khromykh, Yu.M., Effects of Gamma-Radiation in Oogenesis in Drosophila Mutants Defective for Repair and Meiotic Recombination, Genetika (Moscow), vol. 37, no. 6, pp. 770-778.

  5. Lindsley, D.L. and Grell, E.H., Genetic Variations of Drosophila melanogaster, Washington: Carnegie Inst. of Washington Publ., 1986.

    Google Scholar 

  6. King, R.C., Oogenesis in Adult Drosophila melanogaster: 2. Stage Distribution As a Function of Age, Growth, 1957, vol. 21, p. 282.

    Google Scholar 

  7. Abbot, W.S., A Method for Computing the Effectiveness of an Insecticide, J. Econ. Entomol., 1925, vol. 18, pp. 265-267.

    Google Scholar 

  8. Lakin, G.F., Biometriya (Biometry), Moscow: Vysshaya Shkola, 1980.

    Google Scholar 

  9. Baker, B.S. and Hall, J.C., Meiotic Mutants: Genetic Control of Meiotic Recombination and Chromosome Segregation, Genetics and Biology of Drosophila, Ashburner, M. and Novitsky, E., Eds., New York: Academic, 1972, vol. 1, pp. 351-434.

    Google Scholar 

  10. Li, D.E., Deistvie radiatsii na zhivye kletki (The Effect of Radiation on Mature Cells), Moscow: Gosatomizdat, 1963.

    Google Scholar 

  11. Carpenter, A.T.C. and Sandler, L., On Recombination-Defective Meiotic Mutants in Drosophila melanogaster, Genetics, 1974, vol. 76, pp. 453-475.

    Google Scholar 

  12. Khromykh, Yu.M., Varentsova, E.R., and Zakharov, I.A., Drosophila Mutants Hypersensitive to Ionizing Radiation, Dokl. Akad. Nauk SSSR, 1977, vol. 234, p. 199.

    Google Scholar 

  13. Baker, B.S. and Carpenter, A.T.C., Genetic Analysis of Sex-Chromosomal Meiotic Mutants in Drosophila melanogaster, Genetics, 1972, vol. 71, pp. 225-286.

    Google Scholar 

  14. Khromykh, Yu.M., Study of the Genetic and Radiobiological Effects of a Radiosensitivity Mutation in Drosophila, Cand. Sci. (Biol.) Dissertation, Leningrad: Leningrad. Gos. Univ., 1982.

    Google Scholar 

  15. Baker, B.S., Carpenter, A.T.C., and Ripoll, P., The Utilization during Mitotic Cell Division of Loci Controlling Meiotic Recombination and Disjunction in Drosophila melanogaster, Genetics, 1978, vol. 90, pp. 531-578.

    Google Scholar 

  16. Sekelsky, J.J., McKim, K.S., Chin, G.M., and Hawley, R.S., The Drosophila Meiotic Recombination Gene mei-9 Encodes a Homologue of the Yeast Excision Repair Protein Rad1, Genetics, 1995, vol. 141, pp. 619-627.

    Google Scholar 

  17. Sekelsky, J.J., Kenneth, C.B., and Hawley, R.S., Damage Control: The Pleiotropy of DNA Repair Genes in Drosophila melanogaster, Genetics, 1998, vol. 148, pp. 1587-1598.

    Google Scholar 

  18. Hari, K.L., Santerre, A., Sekelsky, J.J., et al., The mei-41 Gene of D. melanogaster Is a Structural and Functional Homolog of the Human Ataxia Telangiectasia Gene, Cell (Cambridge, Mass.), 1995, vol. 82, pp. 815-821.

    Google Scholar 

  19. Banga, S.S., Velasquez, A., and Boyd, J.B., P Transposition in Drosophila Provides a New Tool for Analyzing Postreplication Repair and Double-Strand Break Repair, Mutat. Res., 1991, vol. 255, pp. 79-88.

    Google Scholar 

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  1. St. Petersburg Konstantinov Institute of Nuclear Physics, Gatchina, Leningrad oblast, 188350, Russia

    S. V. Sarantseva & Yu. M. Khromykh

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  1. S. V. Sarantseva
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  2. Yu. M. Khromykh
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Sarantseva, S.V., Khromykh, Y.M. The Interaction of the rad201Gene with Genes mei-9and mei-41in Germline Cells of DrosophilaFemales. Russian Journal of Genetics 37, 764–767 (2001). https://doi.org/10.1023/A:1016742808860

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