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Hyaluronic acid and silver sulfadiazine-impregnated polyurethane foams for wound dressing application

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Abstract

Five different kinds of PU foam wound dressings were prepared to investigate their wound healing capability. They include (i) PU+silver sulfadiazine (AgSD), (ii) PU+alginate (Al), (iii) PU+Al+AgSD, (iv) PU+hyaluronic acid (HA), and (v) PU+HA+AgSD. Physical properties and in vitro behaviors of AgSD release and fibroblast adhesion on those dressings were evaluated. From the drug release and fibroblast adhesion studies, it was observed that PU foam impregnated with both HA and AgSD shows good drug release behavior and low adhesion of the cells. Furthermore, the HA and AgSD-containing PU foam showed excellent wound healing effect without any inflammation or yellow cluster. The wound size decreased around 77% after 1 week application of that foam dressing onto a rat skin defect.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Kwangju Institute of Science and Technology (K-JIST), 1 Oryong-dong, Puk-gu, Kwangju, 500-712, Korea

    Y.-S. Cho, J.-W. Lee & J.-S. Lee

  2. Department of Polymer Science and Engineering, Hannam University, 133 Ojeong-dong, Daedeog-gu, Taejon, 306-791, Korea

    J. H. Lee

  3. Department of Orthopedics, Chonnam University Hospital, 8 Hak-dong, Kwangju, 501-190, Korea

    T. R. Yoon

  4. R & D Center for Artificial Skin, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa, 228-8555, Japan

    Y. Kuroyanagi

  5. Biopol Co. Ltd., 226–8 Baeto-ri Hyangnam-myun, Hwasung-shi, Kyunggi-do, 445-924

    M. H. Park & H. J. Kim

Authors
  1. Y.-S. Cho
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  2. J.-W. Lee
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  3. J.-S. Lee
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  4. J. H. Lee
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  5. T. R. Yoon
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  6. Y. Kuroyanagi
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  7. M. H. Park
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  8. H. J. Kim
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Correspondence to J.-S. Lee.

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Cho, YS., Lee, JW., Lee, JS. et al. Hyaluronic acid and silver sulfadiazine-impregnated polyurethane foams for wound dressing application. Journal of Materials Science: Materials in Medicine 13, 861–865 (2002). https://doi.org/10.1023/A:1016500429225

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  • DOI: https://doi.org/10.1023/A:1016500429225

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