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Biobased multiphase foams with ZnO for wound dressing applications

  • Materials for life sciences
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Abstract

The continuous development of new wound dressing materials is necessary in order to achieve the best skin tissue regeneration properties. In this research, renewable foams, based on thermoplastic polyurethane (TPU) blended with polylactic acid (PLA), with and without 5 wt.% zinc oxide (ZnO) nanofiller were fabricated, and their biocompatibility with fibroblast cells was evaluated. The composites were prepared by thermally induced phase separation method (TIPS) for wound dressing application. These porous materials were structurally and thermally characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform spectroscopy (FTIR). The materials were also tested for their water uptake ability, hydrophilic/hydrophobic properties and water vapor transmission rate (WVTR). The fibroblasts presented a good interaction with these foams by adhering to the materials surface, pointing out that a higher content of TPU is favorable for cell viability. Moreover, no toxic effects of these novel materials were detected. The antibacterial tests showed proper antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. Thus, blending TPU foams with PLA could be validated as biocompatible platforms, suitable for wound dressing application.

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Authors and Affiliations

  1. Faculty of Technology and Metallurgy, Ss Cyril and Methodius University, Rudjer Boskovic 16, 1000, Skopje, North Macedonia

    Aleksandra Bužarovska

  2. Department of Biochemistry and Molecular Biology, University of Bucharest, 050095, Bucharest, Romania

    Aida Selaru, Mirela Serban, Marieta Costache & Sorina Dinescu

  3. Research Institute of the University of Bucharest (ICUB), 050663, Bucharest, Romania

    Gratiela G. Pircalabioru, Marieta Costache & Sorina Dinescu

  4. Institute of Polymer, Composites and Biomaterials - National Research Council of Italy, Via Campi Flegrei, 34 - 80078, Pozzuoli (NA), Italy

    Mariacristina Cocca & Gennaro Gentile

  5. BioTeam/ICPEES-ECPM, UMR CNRS 7515, Université de Strasbourg, 25 rue Becquerel, 67087, Strasbourg Cedex 2, France

    Luc Avérous

Authors
  1. Aleksandra Bužarovska
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  2. Aida Selaru
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Correspondence to Aleksandra Bužarovska or Sorina Dinescu.

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Bužarovska, A., Selaru, A., Serban, M. et al. Biobased multiphase foams with ZnO for wound dressing applications. J Mater Sci 58, 17594–17609 (2023). https://doi.org/10.1007/s10853-023-09119-6

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  • DOI: https://doi.org/10.1007/s10853-023-09119-6

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