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Evidence for an Acute Antimagnesiuretic Effect of Triamterene Derivatives

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Abstract

The acute natriuretic, antikaliuretic and antimagnesiuretic effects of two triamterene derivatives, carboxybutoxytriamterene ethyl amide and dimethylaminohydroxypropoxytriamterene (RPH 2823), are shown in male Wistar rats during urine collection periods of 1 to 2.5 h. In combination with furosemide both compounds reduce the potassium excretion that is caused by the loop diuretic. Furthermore, RPH 2823 strongly decreases the magnesiuresis after application of furosemide, and the ethyl amide derivative (25 µmol/kg) reduces the magnesium losses produced by 25 µmol/kg furosemide close to control values. The evaluation of dose-response curves gave further evidence for the hypothesis that the renal handling of K– and Mg2– is coupled to some extent.

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Authors and Affiliations

  1. Institute of Pharmacology, Department of Biochemistry, Pharmacy and Food Chemistry, University of Frankfurt, D-6000, Fed. Rep. Germany

    Helmut Priewer

  2. Pharmakologisches Institut für Naturwissenschaftler, Theodor-Stern-Kai 7, Geb. 75A, 6000, Frankfurt, Fed. Rep. Germany

    Ernst Mutschler

Authors
  1. Helmut Priewer
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  2. Helga Kraft
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  3. Ernst Mutschler
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Priewer, H., Kraft, H. & Mutschler, E. Evidence for an Acute Antimagnesiuretic Effect of Triamterene Derivatives. Pharm Res 2, 90–93 (1985). https://doi.org/10.1023/A:1016398929981

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