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Anticonvulsant and Monoamine Oxidase Inhibitory Activities of some Triazene N1-Oxides

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Abstract

Thirty-three N 3-2-, -3- or -4-substituted aryl-N 1-(alkyl/aryl/substituted aryl)-triazene N 1-oxides were synthesized and evaluated for their anticonvulsant and monoamine oxidase (MAO) inhibitory activities. Most of the compounds exhibited MAO inhibitory activity in vitro, and kinetic studies conducted with N 3-4-chlorophenyl-N 1-methyltriazene N 1-oxide, the most potent inhibitor, showed that the inhibition is non-competitive in nature. The MAO inhibiting activity of the compounds correlated well with their anticonvulsant effect against maximal electroshock-induced seizures in rats. Acute toxicity studies indicate that the compounds have a wide margin of safety.

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Authors and Affiliations

  1. Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banares Hindu University, Varanasi, India

    Ashok Kumar

  2. Department of Chemistry, University of Rajasthan, Jaipur, India

    S. K. Mukerjee

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  1. Ashok Kumar
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  2. S. K. Mukerjee
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  3. S. K. Bhattacharya
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Kumar, A., Mukerjee, S.K. & Bhattacharya, S.K. Anticonvulsant and Monoamine Oxidase Inhibitory Activities of some Triazene N1-Oxides. Pharm Res 2, 49–52 (1985). https://doi.org/10.1023/A:1016374224529

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