Abstract
Knowledge of genes responsible for aging and death is a prerequisite for determining the relative contributions of the different evolutionary factors responsible for the limited duration of life. Polymorphism of these genes probably accounts for the variation in lifespan. Previously, quantitative trait loci (QTLs) controlling this variation were mapped with the use of 98 recombinant inbred (RI) lines originating from two parental isogenicDrosophila melanogaster stocks. In each RI line, lifespan was measured for 25 males and 25 females, and alleles were established for 93 marker genes segregating between the parental lines. Significant correlation between marker segregation and lifespan was revealed for several chromosome regions. The lifespan genes had sex-specific effects and late age onset. In the present work, the effects of the QTLs were compared for homozygous and heterozygous flies. In Six out of the eight detected QTLs alleles that decreased lifespan were recessive. Heterosis was observed for a of QTL at 33E–38A. Thus, heterosis might contribute to maintaining variation in lifespan in natural populations.
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REFERENCES
Rose, M.R., Evolutionary Biology of Aging, Oxford: Oxford Univ. Press, 1991.
Ewbank, J.J., Barnes, T.M., Lakowski, B., et al., Structural and Functional Conservation of the Caenorhabdites elegans Timing Gene clk-1, Science, 1997, vol. 275, pp. 980-983.
Coates, P.J., Jamieson, D.J., Smart, K., et al., The Prohibitin Family of Mitochondrial Proteins Regulate Replicative Lifespan, Curr. Biol., 1997, no. 7, pp. 607-610.
Jazwinski, S.M., Longevity, Genes, and Aging, Science, 1996, vol. 273, pp. 54-59.
Bodnar, A.G., Ouellette, M., Frolkis, M., et al., Extension of Life-Span by Introduction of Telomerase into Normal Human Cells, Science, 1998, vol. 279, pp. 349-352.
Kaiser, M., Gasser, M., Ackermann, R., and Stearns, S.C., P-Element Inserts in Transgenic Flies: A Cautionary Tale, Heredity, 1998, vol. 78, pp. 1-11.
Charlesworth, B. and Partridge, L., Aging: Leveling of the Grim Reaper, Curr. Biol., 1997, no. 7, pp. R440-R442.
Rose, M.R., Antagonistic Pleiotropy, Dominance, and Genetic Variation, Heredity, 1982, vol. 48, pp. 63-78.
Rose, M.R., Life History Evolution with Antagonistic Pleiotropy and Overlapping Generations, Theor. Pop. Biol., 1985, vol. 28, pp. 342-358.
Hutchinson, E.W. and Rose, M.R., Quantitative Genetics of Postponed Aging in Drosophila melanogaster: I. Analysis of Outbred Populations, Genetics, 1991, vol. 127, pp. 719-727.
Hutchinson, E.W., Shaw, A.J., and Rose, M.R., Quantitative Genetics of Postponed Aging in Drosophila melanogaster: I. Analysis of Selected Lines, Genetics, 1991, vol. 127, pp. 729-737.
Nuzhdin, S.V., Pasyukova, E.G., Dilda, C.A., et al., Sex-Specific Quantitative Trait Loci Affecting Longevity in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA, 1997, vol. 94, pp. 9734-9739.
Vieira, C., Pasyukova, E.G., Zeng, Z.B., et al., Genotype-Environment Interaction for Quantitative Trait Loci Affecting Life Span in Drosophila melanogaster, Genetics, 2000, vol. 154, pp. 213-227.
Nuzhdin, S.V., Keightley, P.D., Pasyukova, E.G., and Marozova, E.A., Quantitative Trait Loci Mapping in the Course of Divergent Selection for Sternopleural Bristle Number of Drosophila melanogaster, Genet. Res., 1998, vol. 72, pp. 79-91.
Lindsley, D.L. and Zimm G.G., The Genome of Drosophila melanogaster, San Diego: Academic, 1992.
Pasyukova, E.G. and Nuzhdin, S.V., Doc and copia Instability in an Isogenic Drosophila melanogaster stock, Mol. Gen. Genet., 1993, vol. 240, pp. 302-306.
SAS/STAT User's Guide, Release 6.03 Edition, Cary, NC: SAS Inst., 1988.
Basten, C.J., Weir, B.S., and Zeng, Z.-B., Zmap-a QTL Cartographer, Proc. 5th World Congr. on Genetics Applied to Livestock Production: Computing Strategies and Software, Smith, C., Gavora, J.S., Benkel, B., et al., Eds., 1994, vol. 22, pp. 65-66.
Basten, C.J., Weir, B.S., and Zeng, Z.-B., QTL Cartographer, Version 1.1.3, Raleigh, NC: North Carolina State Univ., 1999.
Zeng, Z.-B., Precision Mapping of Quantitative Trait Loci, Genetics, 1994, vol. 136, pp. 1457-1468.
Doerge, R.W., Zeng, Z.-B., and Weir, B.S., Statistical Issues in the Search for Genes Affecting Quantitative Traits in Experimental Populations, Stat. Sci., 1997, vol. 12, pp. 195-219.
Gowen, J.W. and Johnson, L.E., On the Mechanism of Heterosis: I. Metabolic Capacity of Different Races of Drosophila melanogaster for Egg Production, Am. Nat., 1946, vol. 80, pp. 149-179.
Clarke, J.M. and Maynard Smith, J., The Genetics and Cytology of Drosophila subobscura: XI. Hybrid Vigor and Longevity, J. Genet., 1955, vol. 53, pp. 172-180.
Gurganus, M.C., Fry, J.D., Nuzhdin, S.V., et al., Genotype-Environment Interaction for Quantitative Trait Loci Affecting Sensory Bristle Number in Drosophila melanogaster, Genetics, 1998, vol. 149, pp. 1883-1898.
Wayne, M.L., Hackett, J.B., Dilda, C.L., et al., Quantitative Trait Locus Mapping of Fitness-Related Traits in Drosophila melanogaster: Ovariole Number, Body Size, Early Fecundity, and Reproductive Success, submitted for publication in Genet. Res.
_ Lynch, M. and Walsh, B., Genetics and Analysis of Quantitative Traits, Sunderland, 1998.
Beavis, W.D., The Power and Deceit of QTL Experiments: Lessons from Comparative QTL Studies, 49th Ann. Corn and Sorghum Res. Conf., Washington, DC: Am. Seed Trade Association, 1994, pp. 252-268.
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Nuzhdin, S.V., Reiwitch, S.G. Heterosis of Quantitative Trait Loci Affecting Lifespan in Drosophila melanogaster. Russian Journal of Genetics 38, 766–770 (2002). https://doi.org/10.1023/A:1016335504009
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DOI: https://doi.org/10.1023/A:1016335504009